Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3505782..3506400 Replicon chromosome
Accession NZ_CP046416
Organism Escherichia coli strain LZYWN_4

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag GJV83_RS17090 Protein ID WP_001291435.1
Coordinates 3506182..3506400 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag GJV83_RS17085 Protein ID WP_000344800.1
Coordinates 3505782..3506156 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV83_RS17075 3500871..3502064 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GJV83_RS17080 3502087..3505236 + 3150 WP_001132469.1 multidrug efflux RND transporter permease subunit -
GJV83_RS17085 3505782..3506156 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
GJV83_RS17090 3506182..3506400 + 219 WP_001291435.1 hemolysin expression modulator Hha Toxin
GJV83_RS17095 3506572..3507123 + 552 WP_000102564.1 maltose O-acetyltransferase -
GJV83_RS17100 3507239..3507709 + 471 WP_000136192.1 YlaC family protein -
GJV83_RS17105 3507873..3509423 + 1551 WP_001310610.1 cyclic-guanylate-specific phosphodiesterase PdeB -
GJV83_RS17110 3509465..3509818 - 354 WP_000878140.1 DUF1428 domain-containing protein -
GJV83_RS17120 3510197..3510508 + 312 WP_000409911.1 MGMT family protein -
GJV83_RS17125 3510539..3511111 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T144245 WP_001291435.1 NZ_CP046416:3506182-3506400 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T144245 NZ_CP061800:1833476-1833871 [Desulfonema magnum]
ATGTATCTGTTAGATACAAACATCTGTATTTATATCATAAATAAAAAACCTGCTTCTGTTGTTGAAAAAATAAAAACTCT
CAACCCTAATGACATTAAGCTGTCTTCCATCTCTGTCGGAGAATTGGAGTACGGGGTGTCAAAAAGTACAAACAGAGAAA
AAAACAGAAATGCACTTGTGGAATTTGTCTCCTGCTTTGACATTCTCAGCTTCAATGATTCCGATGCAGAAGTATTTGGC
ATGATAAGAGCATATTTAGAGAAGAAAGGAACAGTCATAGGACCCTATGACATGCAAATTGCTGCCCAGGCTATTTCATG
TAAACTGACCCTGATTACTAATAATACTAAAGAATTTATTCGAATACCTGAACTTATGCTTGATAATTGGATTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT144245 WP_000344800.1 NZ_CP046416:3505782-3506156 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT144245 NZ_CP061800:1833246-1833476 [Desulfonema magnum]
ATGTTAAGTTCAAAAGTTTTTATAAGCGGAAACAGTCAGGCTGTAAGATTGCCAAAGGAGTATCAGGTAAGTGAAAAGGA
ATTATTTATTCAGAAAATAGGAAACACTATCATTCTGTTTCCCAAAAGTAACCCGTGGGAAGCATTTGAACACAGTCTGA
ATGAATTTACCGAAGATTTTATGCAGGAGGGAAGAAATCAGCCGGCTATGCAGGAAAGAGACGGATTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References