Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2418900..2420488 Replicon chromosome
Accession NZ_CP046416
Organism Escherichia coli strain LZYWN_4

Toxin (Protein)


Gene name hipA Uniprot ID S1ELM3
Locus tag GJV83_RS11910 Protein ID WP_001125439.1
Coordinates 2419166..2420488 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag GJV83_RS11905 Protein ID WP_001301023.1
Coordinates 2418900..2419166 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV83_RS11905 2418900..2419166 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
GJV83_RS11910 2419166..2420488 + 1323 WP_001125439.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
GJV83_RS11915 2420774..2421721 - 948 WP_001138411.1 hypothetical protein -
GJV83_RS11920 2422537..2423082 - 546 WP_206969814.1 cell envelope integrity protein TolA -
GJV83_RS11925 2423222..2424429 + 1208 WP_089617520.1 IS3 family transposase -
GJV83_RS11930 2424426..2424980 - 555 WP_206969817.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49275.82 Da        Isoelectric Point: 8.2482

>T144243 WP_001125439.1 NZ_CP046416:2419166-2420488 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

>T144243 NZ_CP061800:c145376-145095 [Desulfonema magnum]
ATGATCAAATCTTTTAAAGACAAAGAAACCGAAAAAATATTTTGCCTCAGACGTTCACGCAGACTGCCCCCTGAAATTCA
GCAGACGGCTTTGCGTAAGCTCCGTATGCTGAACAACGCCCAGAATTTGCAGGACTTGCGTGTTCCGCCTGCGAACCGGC
TGGAAAAGCTGACAAAGGATCGGGCGGGGCAGCACAGCATCCGAATTAACGATCAGTGGCGTATCTGCTTTGAATGGCGG
AACGGTGATGCTTATGAGGCGGAAATCACAGATTACCATTAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT144243 WP_001301023.1 NZ_CP046416:2418900-2419166 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp

>AT144243 NZ_CP061800:c145081-144773 [Desulfonema magnum]
ATGACACAGGACAAACTGAATCCGGTTCATCCCGGCGAAATTCTGGCTGAGGAATTTTTAAAACCCATGGGGCTGACCCC
GGAACAACTGGCATCTGATATCGGCGTAAACATCACTCAGCTTGACAAAATCATAGCGGAAAAAGAGGGAATGAATGCGG
ACATGGCCCTTCGGCTGGCCCGCTACTTCGGAACATCTCCCCGTTTTTGGACGGGCCTGCAGGCGGATTATGATCTGGAT
GTGACATCGGAATATCTGGGAAACCGTCTGGAACAGGAAGTGAAACCCCGGGCCGTCGCTGCCGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5K98
PDB 3TPV
PDB 3DNV
PDB 3TPD
PDB 3HZI
PDB 3FBR
PDB 4YG7
PDB 3TPE
PDB 2WIU
PDB 3DNT
PDB 3TPB
PDB 3TPT
PDB 3DNU

Antitoxin

Source ID Structure

References