Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2418900..2420488 | Replicon | chromosome |
Accession | NZ_CP046416 | ||
Organism | Escherichia coli strain LZYWN_4 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | S1ELM3 |
Locus tag | GJV83_RS11910 | Protein ID | WP_001125439.1 |
Coordinates | 2419166..2420488 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | GJV83_RS11905 | Protein ID | WP_001301023.1 |
Coordinates | 2418900..2419166 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJV83_RS11905 | 2418900..2419166 | + | 267 | WP_001301023.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
GJV83_RS11910 | 2419166..2420488 | + | 1323 | WP_001125439.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
GJV83_RS11915 | 2420774..2421721 | - | 948 | WP_001138411.1 | hypothetical protein | - |
GJV83_RS11920 | 2422537..2423082 | - | 546 | WP_206969814.1 | cell envelope integrity protein TolA | - |
GJV83_RS11925 | 2423222..2424429 | + | 1208 | WP_089617520.1 | IS3 family transposase | - |
GJV83_RS11930 | 2424426..2424980 | - | 555 | WP_206969817.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49275.82 Da Isoelectric Point: 8.2482
>T144243 WP_001125439.1 NZ_CP046416:2419166-2420488 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK
Download Length: 1323 bp
>T144243 NZ_CP061800:c145376-145095 [Desulfonema magnum]
ATGATCAAATCTTTTAAAGACAAAGAAACCGAAAAAATATTTTGCCTCAGACGTTCACGCAGACTGCCCCCTGAAATTCA
GCAGACGGCTTTGCGTAAGCTCCGTATGCTGAACAACGCCCAGAATTTGCAGGACTTGCGTGTTCCGCCTGCGAACCGGC
TGGAAAAGCTGACAAAGGATCGGGCGGGGCAGCACAGCATCCGAATTAACGATCAGTGGCGTATCTGCTTTGAATGGCGG
AACGGTGATGCTTATGAGGCGGAAATCACAGATTACCATTAG
ATGATCAAATCTTTTAAAGACAAAGAAACCGAAAAAATATTTTGCCTCAGACGTTCACGCAGACTGCCCCCTGAAATTCA
GCAGACGGCTTTGCGTAAGCTCCGTATGCTGAACAACGCCCAGAATTTGCAGGACTTGCGTGTTCCGCCTGCGAACCGGC
TGGAAAAGCTGACAAAGGATCGGGCGGGGCAGCACAGCATCCGAATTAACGATCAGTGGCGTATCTGCTTTGAATGGCGG
AACGGTGATGCTTATGAGGCGGAAATCACAGATTACCATTAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 10016.38 Da Isoelectric Point: 6.2267
>AT144243 WP_001301023.1 NZ_CP046416:2418900-2419166 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW
Download Length: 267 bp
>AT144243 NZ_CP061800:c145081-144773 [Desulfonema magnum]
ATGACACAGGACAAACTGAATCCGGTTCATCCCGGCGAAATTCTGGCTGAGGAATTTTTAAAACCCATGGGGCTGACCCC
GGAACAACTGGCATCTGATATCGGCGTAAACATCACTCAGCTTGACAAAATCATAGCGGAAAAAGAGGGAATGAATGCGG
ACATGGCCCTTCGGCTGGCCCGCTACTTCGGAACATCTCCCCGTTTTTGGACGGGCCTGCAGGCGGATTATGATCTGGAT
GTGACATCGGAATATCTGGGAAACCGTCTGGAACAGGAAGTGAAACCCCGGGCCGTCGCTGCCGGGTAG
ATGACACAGGACAAACTGAATCCGGTTCATCCCGGCGAAATTCTGGCTGAGGAATTTTTAAAACCCATGGGGCTGACCCC
GGAACAACTGGCATCTGATATCGGCGTAAACATCACTCAGCTTGACAAAATCATAGCGGAAAAAGAGGGAATGAATGCGG
ACATGGCCCTTCGGCTGGCCCGCTACTTCGGAACATCTCCCCGTTTTTGGACGGGCCTGCAGGCGGATTATGATCTGGAT
GTGACATCGGAATATCTGGGAAACCGTCTGGAACAGGAAGTGAAACCCCGGGCCGTCGCTGCCGGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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