144242

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2352191..2352717 Replicon chromosome
Accession NZ_CP046416
Organism Escherichia coli strain LZYWN_4

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag GJV83_RS11545 Protein ID WP_000323025.1
Coordinates 2352430..2352717 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag GJV83_RS11540 Protein ID WP_000534858.1
Coordinates 2352191..2352430 (+) Length 80 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GJV83_RS11505 2348260..2348370 + 111 WP_021531328.1 hypothetical protein -
GJV83_RS11510 2348390..2349670 - 1281 WP_000876979.1 site-specific integrase -
GJV83_RS11515 2349705..2349956 - 252 WP_000005552.1 excisionase family protein -
GJV83_RS11520 2350029..2350373 - 345 WP_001487236.1 3'-5' exoribonuclease -
GJV83_RS11525 2350441..2351138 + 698 Protein_2256 IS1-like element IS1A family transposase -
GJV83_RS11530 2351326..2351658 - 333 WP_001301033.1 protein FlxA -
GJV83_RS11535 2351861..2352166 - 306 WP_071593935.1 hypothetical protein -
GJV83_RS11540 2352191..2352430 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
GJV83_RS11545 2352430..2352717 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
GJV83_RS11550 2352789..2352944 + 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
GJV83_RS11555 2353161..2353412 + 252 WP_001463433.1 hypothetical protein -
GJV83_RS11560 2353479..2353757 + 279 WP_001515373.1 hypothetical protein -
GJV83_RS11565 2353759..2354808 + 1050 WP_001515372.1 DUF968 domain-containing protein -
GJV83_RS11570 2354826..2355203 + 378 WP_206970412.1 antitermination protein -
GJV83_RS11575 2355359..2355883 - 525 WP_000780584.1 lipocalin family protein -
GJV83_RS11580 2356076..2357035 + 960 WP_206970413.1 DUF1722 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2326426..2383596 57170


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T144242 WP_000323025.1 NZ_CP046416:2352430-2352717 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T144242 NZ_CP061799:6343023-6343409 [Desulfonema limicola]
ATGAAACTTCTTTTAGATACACATGTTTTCCTTTGGTATATCAGCAAAGACAGCCGGCTGCCAAACGCAATGCTCGAAAA
CATACGAAATCCTGACAATGAAGTTTTTTTAAGCGTTGTATCTGTATGGGAGACAATTATCAAGTATCAGATTGGCAAAT
TACCGTTACCGCAAAGTCCTGAGATATATTTGCCAACCCAACGTAAACGTCATTCAATTTCAAGTTTGATTTTGGATGAA
TCAAGTGTCTGCCATCTTTCAAAACTGCCTTCTATTCATCGGGACCCTTTTGATCGAATACTTATTTGTCAGGCAATAGA
ACATGGATTAACAATTGCAACAATAGATAATGCAATCAAATCTTATGCTGTGAACATTTTGAAATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT144242 WP_000534858.1 NZ_CP046416:2352191-2352430 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT144242 NZ_CP061799:6342790-6343026 [Desulfonema limicola]
ATGATTTCTGTTACCATTGATGATATCCAGCAAGATTTACTTTATTATCTCAAACAAATAAATTTTGGTGAAACGGTTAT
AATTCTACAAGCTGATAAACCAATAGCAGAATTAAAACCGATTTCAGACTCAAAAATACTGCGTCCATTTGGTTTGTGTG
AGGGAGAATTCACTGTACCGGATGATTTTGATGAACCGCTGCCAGAGAATATAATTCAGGAATTTGAGGGACAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9


Antitoxin

Source ID Structure
AlphaFold DB A0A4V1CTS8

References