Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 2352191..2352717 | Replicon | chromosome |
Accession | NZ_CP046416 | ||
Organism | Escherichia coli strain LZYWN_4 |
Toxin (Protein)
Gene name | relE | Uniprot ID | S1EXL1 |
Locus tag | GJV83_RS11545 | Protein ID | WP_000323025.1 |
Coordinates | 2352430..2352717 (+) | Length | 96 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | S1F6D3 |
Locus tag | GJV83_RS11540 | Protein ID | WP_000534858.1 |
Coordinates | 2352191..2352430 (+) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
GJV83_RS11505 | 2348260..2348370 | + | 111 | WP_021531328.1 | hypothetical protein | - |
GJV83_RS11510 | 2348390..2349670 | - | 1281 | WP_000876979.1 | site-specific integrase | - |
GJV83_RS11515 | 2349705..2349956 | - | 252 | WP_000005552.1 | excisionase family protein | - |
GJV83_RS11520 | 2350029..2350373 | - | 345 | WP_001487236.1 | 3'-5' exoribonuclease | - |
GJV83_RS11525 | 2350441..2351138 | + | 698 | Protein_2256 | IS1-like element IS1A family transposase | - |
GJV83_RS11530 | 2351326..2351658 | - | 333 | WP_001301033.1 | protein FlxA | - |
GJV83_RS11535 | 2351861..2352166 | - | 306 | WP_071593935.1 | hypothetical protein | - |
GJV83_RS11540 | 2352191..2352430 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
GJV83_RS11545 | 2352430..2352717 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
GJV83_RS11550 | 2352789..2352944 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
GJV83_RS11555 | 2353161..2353412 | + | 252 | WP_001463433.1 | hypothetical protein | - |
GJV83_RS11560 | 2353479..2353757 | + | 279 | WP_001515373.1 | hypothetical protein | - |
GJV83_RS11565 | 2353759..2354808 | + | 1050 | WP_001515372.1 | DUF968 domain-containing protein | - |
GJV83_RS11570 | 2354826..2355203 | + | 378 | WP_206970412.1 | antitermination protein | - |
GJV83_RS11575 | 2355359..2355883 | - | 525 | WP_000780584.1 | lipocalin family protein | - |
GJV83_RS11580 | 2356076..2357035 | + | 960 | WP_206970413.1 | DUF1722 domain-containing protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | - | - | 2326426..2383596 | 57170 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T144242 WP_000323025.1 NZ_CP046416:2352430-2352717 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T144242 NZ_CP061799:6343023-6343409 [Desulfonema limicola]
ATGAAACTTCTTTTAGATACACATGTTTTCCTTTGGTATATCAGCAAAGACAGCCGGCTGCCAAACGCAATGCTCGAAAA
CATACGAAATCCTGACAATGAAGTTTTTTTAAGCGTTGTATCTGTATGGGAGACAATTATCAAGTATCAGATTGGCAAAT
TACCGTTACCGCAAAGTCCTGAGATATATTTGCCAACCCAACGTAAACGTCATTCAATTTCAAGTTTGATTTTGGATGAA
TCAAGTGTCTGCCATCTTTCAAAACTGCCTTCTATTCATCGGGACCCTTTTGATCGAATACTTATTTGTCAGGCAATAGA
ACATGGATTAACAATTGCAACAATAGATAATGCAATCAAATCTTATGCTGTGAACATTTTGAAATAA
ATGAAACTTCTTTTAGATACACATGTTTTCCTTTGGTATATCAGCAAAGACAGCCGGCTGCCAAACGCAATGCTCGAAAA
CATACGAAATCCTGACAATGAAGTTTTTTTAAGCGTTGTATCTGTATGGGAGACAATTATCAAGTATCAGATTGGCAAAT
TACCGTTACCGCAAAGTCCTGAGATATATTTGCCAACCCAACGTAAACGTCATTCAATTTCAAGTTTGATTTTGGATGAA
TCAAGTGTCTGCCATCTTTCAAAACTGCCTTCTATTCATCGGGACCCTTTTGATCGAATACTTATTTGTCAGGCAATAGA
ACATGGATTAACAATTGCAACAATAGATAATGCAATCAAATCTTATGCTGTGAACATTTTGAAATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT144242 WP_000534858.1 NZ_CP046416:2352191-2352430 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT144242 NZ_CP061799:6342790-6343026 [Desulfonema limicola]
ATGATTTCTGTTACCATTGATGATATCCAGCAAGATTTACTTTATTATCTCAAACAAATAAATTTTGGTGAAACGGTTAT
AATTCTACAAGCTGATAAACCAATAGCAGAATTAAAACCGATTTCAGACTCAAAAATACTGCGTCCATTTGGTTTGTGTG
AGGGAGAATTCACTGTACCGGATGATTTTGATGAACCGCTGCCAGAGAATATAATTCAGGAATTTGAGGGACAATGA
ATGATTTCTGTTACCATTGATGATATCCAGCAAGATTTACTTTATTATCTCAAACAAATAAATTTTGGTGAAACGGTTAT
AATTCTACAAGCTGATAAACCAATAGCAGAATTAAAACCGATTTCAGACTCAAAAATACTGCGTCCATTTGGTTTGTGTG
AGGGAGAATTCACTGTACCGGATGATTTTGATGAACCGCTGCCAGAGAATATAATTCAGGAATTTGAGGGACAATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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