Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
| Location | 1039219..1039802 | Replicon | chromosome |
| Accession | NZ_CP046416 | ||
| Organism | Escherichia coli strain LZYWN_4 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | S1EZP4 |
| Locus tag | GJV83_RS05030 | Protein ID | WP_000254738.1 |
| Coordinates | 1039467..1039802 (+) | Length | 112 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | S1P3W5 |
| Locus tag | GJV83_RS05025 | Protein ID | WP_000581937.1 |
| Coordinates | 1039219..1039467 (+) | Length | 83 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GJV83_RS05015 | 1035558..1036859 | + | 1302 | WP_000046812.1 | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD | - |
| GJV83_RS05020 | 1036907..1039141 | + | 2235 | WP_000226815.1 | GTP pyrophosphokinase | - |
| GJV83_RS05025 | 1039219..1039467 | + | 249 | WP_000581937.1 | type II toxin-antitoxin system antitoxin MazE | Antitoxin |
| GJV83_RS05030 | 1039467..1039802 | + | 336 | WP_000254738.1 | endoribonuclease MazF | Toxin |
| GJV83_RS05035 | 1039873..1040664 | + | 792 | WP_001071648.1 | nucleoside triphosphate pyrophosphohydrolase | - |
| GJV83_RS05040 | 1040892..1042529 | + | 1638 | WP_000210878.1 | CTP synthase (glutamine hydrolyzing) | - |
| GJV83_RS05045 | 1042617..1043915 | + | 1299 | WP_000036723.1 | phosphopyruvate hydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 112 a.a. Molecular weight: 12098.04 Da Isoelectric Point: 8.2618
>T144232 WP_000254738.1 NZ_CP046416:1039467-1039802 [Escherichia coli]
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKS
IAWRARGATKKGTVAPEELQLIKAKINVLIG
Download Length: 336 bp
>T144232 NZ_CP061799:c161530-161195 [Desulfonema limicola]
ATGGATATTACTTTTAAAACTAAAAAACTTAAAAAAATCTTTAACAATTCAAAATTATTGATTAAAGAATATGGTGAACA
GACTGCTGATAAAATACAGATAAGAATGATAGTTCTTAGGTCAGCAAATAATTTAGATCTAGTTCCAAAAACTCCACCTG
ATAGATGCCATCAATTAACAAATAATAGAAAAGAAACATTTGCTGTTGATTTGAAACACCCTTTTAGATTGATTTTTAAA
CCTGATATGGAGGAAATACCTAAACTGAGTGATGGAGGAATAGATTTAAAGGAAATTAATGTAATCAAAATTTTAGGAGT
GGAGGATTATCACTAA
ATGGATATTACTTTTAAAACTAAAAAACTTAAAAAAATCTTTAACAATTCAAAATTATTGATTAAAGAATATGGTGAACA
GACTGCTGATAAAATACAGATAAGAATGATAGTTCTTAGGTCAGCAAATAATTTAGATCTAGTTCCAAAAACTCCACCTG
ATAGATGCCATCAATTAACAAATAATAGAAAAGAAACATTTGCTGTTGATTTGAAACACCCTTTTAGATTGATTTTTAAA
CCTGATATGGAGGAAATACCTAAACTGAGTGATGGAGGAATAGATTTAAAGGAAATTAATGTAATCAAAATTTTAGGAGT
GGAGGATTATCACTAA
Antitoxin
Download Length: 83 a.a. Molecular weight: 9355.74 Da Isoelectric Point: 4.4665
>AT144232 WP_000581937.1 NZ_CP046416:1039219-1039467 [Escherichia coli]
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
MIHSSVKRWGNSPAVRIPATLMQALNLNIDDEVKIDLVDGKLIIEPVRKEPVFTLAELVNDITPENLHENIDWGEPKDKE
VW
Download Length: 249 bp
>AT144232 NZ_CP061799:c161195-160101 [Desulfonema limicola]
ATGAATTATTTAAATCAATTTAATCCAGACTATGCAATACATCCAGGAGTTTATATTGAAGAAATACTCGAAGCAAGAAA
AATGAAAAAAAGTGACTTTGCTGAAAGATGTGGTATTTCATCTAAAACTATTAGCCAAATCATTAACAAAAAAGTATTGT
TTTCTGCTGATGCTGCAGTGCGTTTTGAAAAAGTTTTAGGTGTCAATGCAGATTTGTTAATGAATATGTCAACATCATAT
CAGATGTTTGAGATAAGAGAGGGAAAAAAAAATGAATTGAAAAAAAAAGCTGAATGGTTAAAAAAATTTCCATATAAAGA
GCTAATAAAATTCAATATTATACAAAGCAGTAATGACATTTCTGATTTAGCGAATTCTCTTTTAGATTTTTTTAATGTTT
CATCGCCATCTATTTGGGACGAATATTATTCTAATAAAGCCATTTCATTTAGAAAGTCAAAAAATTACAAAAGCTCTCTA
CATTCAACAATGACTTGGTTAAGAATTGGAGAAAAACTATCAGAAGAAATTGAATGCAAAAATTTTAATATAGGAGTATT
TAAAGAAAATTTAAAAGAAATAAAAAAGTTAACCAAGTTGTCTCTAAATAAATTTGAGCCTGAAATAAAAAAACTGTGTA
ATGATTCAGGAGTGGCACTTGTATTAATCCCTGAATTCAAAGGTATGAGAATTAGCGGAATTACAGAATGGCTTACTCCC
AAAAAAGCTTTAATTTTAATGAGTTTACGATACAAAACTAATGACCATTTCTGGTTTACTTTTTTTCATGAAGCAGGGCA
TATTATTTTACACAACAAAAAAGACATCTTTATTGATGGTATTGATAACAAAGACATTTCAGATATTGAAAAAGAAGCTG
ATGTATTTGCGAGAAAAACTCTTATAAATCAAGCTAATTATGATAAGTTTGTTGAATCAAAAAAATTTTATAAAAATAAT
ATTGTTAAGTTTGCTAATCAAAACAATATTGCACCTGGAATCATTGTAGGTATGCTGCAACACGATAAATTAATTAATTA
CTCCTGGCATAATAATTTAAAGGAAAAATTTCCATTGCAATTAAAACTTAAATAA
ATGAATTATTTAAATCAATTTAATCCAGACTATGCAATACATCCAGGAGTTTATATTGAAGAAATACTCGAAGCAAGAAA
AATGAAAAAAAGTGACTTTGCTGAAAGATGTGGTATTTCATCTAAAACTATTAGCCAAATCATTAACAAAAAAGTATTGT
TTTCTGCTGATGCTGCAGTGCGTTTTGAAAAAGTTTTAGGTGTCAATGCAGATTTGTTAATGAATATGTCAACATCATAT
CAGATGTTTGAGATAAGAGAGGGAAAAAAAAATGAATTGAAAAAAAAAGCTGAATGGTTAAAAAAATTTCCATATAAAGA
GCTAATAAAATTCAATATTATACAAAGCAGTAATGACATTTCTGATTTAGCGAATTCTCTTTTAGATTTTTTTAATGTTT
CATCGCCATCTATTTGGGACGAATATTATTCTAATAAAGCCATTTCATTTAGAAAGTCAAAAAATTACAAAAGCTCTCTA
CATTCAACAATGACTTGGTTAAGAATTGGAGAAAAACTATCAGAAGAAATTGAATGCAAAAATTTTAATATAGGAGTATT
TAAAGAAAATTTAAAAGAAATAAAAAAGTTAACCAAGTTGTCTCTAAATAAATTTGAGCCTGAAATAAAAAAACTGTGTA
ATGATTCAGGAGTGGCACTTGTATTAATCCCTGAATTCAAAGGTATGAGAATTAGCGGAATTACAGAATGGCTTACTCCC
AAAAAAGCTTTAATTTTAATGAGTTTACGATACAAAACTAATGACCATTTCTGGTTTACTTTTTTTCATGAAGCAGGGCA
TATTATTTTACACAACAAAAAAGACATCTTTATTGATGGTATTGATAACAAAGACATTTCAGATATTGAAAAAGAAGCTG
ATGTATTTGCGAGAAAAACTCTTATAAATCAAGCTAATTATGATAAGTTTGTTGAATCAAAAAAATTTTATAAAAATAAT
ATTGTTAAGTTTGCTAATCAAAACAATATTGCACCTGGAATCATTGTAGGTATGCTGCAACACGATAAATTAATTAATTA
CTCCTGGCATAATAATTTAAAGGAAAAATTTCCATTGCAATTAAAACTTAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|