Detailed information of TA system TA144226

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 930255..931837
• Replicon: chromosome
• Accession: NZ_CP046415
• Organism: Guyparkeria halophila strain sp2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: GM160_RS04305
• Protein ID: WP_156573444.1
• Coordinates: 930521..931837 (+)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: GM160_RS04300
• Protein ID: WP_156573442.1
• Coordinates: 930255..930527 (+)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GM160_RS04285	926291..927493	-	1203	WP_156573440.1	hypothetical protein	-
GM160_RS04290	927758..928570	-	813	WP_156227540.1	IS21-like element helper ATPase IstB	-
GM160_RS04295	928567..929580	-	1014	WP_156227542.1	IS21 family transposase	-
GM160_RS11820	929755..929940	+	186	WP_197039233.1	hypothetical protein	-
GM160_RS04300	930255..930527	+	273	WP_156573442.1	helix-turn-helix domain-containing protein	Antitoxin
GM160_RS04305	930521..931837	+	1317	WP_156573444.1	type II toxin-antitoxin system HipA family toxin	Toxin
GM160_RS04310	932461..934176	+	1716	WP_156573446.1	type I restriction-modification system subunit M	-
GM160_RS04315	934166..935698	+	1533	WP_156573448.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (7-107)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-64)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 48709.71 Da
• Isoelectric Point: 6.5038

>T144226 WP_156573444.1 NZ_CP046415:930521-931837 [Guyparkeria halophila]
MVTSRSLDVWMNGYAVGRLTKGAAGEMLFVYADAWLAQEGSRPISLSMPLRQGAYRGDVVYNFFDNLLPDSRPIRDRVQA
RFRVPSSQPFDLLEAIGMDCVGAVQLVPEGASPPDVHVISGEPLAAPAIAGMLEDYQRRPLGMGGGENPFRLSLAGAQEK
TALLWHEGRWMEPHGATPTTHILKLPIGRIEHSGIDLADSCENEWLCLEIVRAFGLPACQAVISEFDGIKTLVVERFDRL
RLEGWIARLPQEDVCQALGLSPNLKYESDGGPGMSDVMGLLWRSERARTDRRQFFKSQALFWLLAAVDGHAKNFSLFIRP
YGRFHLTPLYDVMSVYPLLENGALSRRDARMAMAFRGRNAHYRWHEILPRHVVAAGERAGLSSREVVECFSDVVSRIDDA
LSRVESSLPAEFPDTVAEPIFAGIRRQGERAAKYLAST

Nucleotide

• Length: 1317 bp

>T144226 NZ_CP061780:c553794-553039 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGTTGGGGG
TCGCGGTTTGGCCGTCGTCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGCAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGTGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGGAGTGCCATACGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10073.25 Da
• Isoelectric Point: 4.8232

>AT144226 WP_156573442.1 NZ_CP046415:930255-930527 [Guyparkeria halophila]
MLIQSTDELAGYFRDRRKSRVLTQVAVAEDARLRQGTVSAFERSPDSTRLDTVFRLLDALDLELHVVPKESPDARTAGVT
GGEQGWSEPW

Nucleotide

• Length: 273 bp

>AT144226 NZ_CP061780:c554297-553929 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCTGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA