Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 46891..48015 Replicon chromosome
Accession NZ_CP046415
Organism Guyparkeria halophila strain sp2

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag GM160_RS00215 Protein ID WP_156575280.1
Coordinates 46891..47634 (-) Length 248 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag GM160_RS00220 Protein ID WP_156227243.1
Coordinates 47647..48015 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GM160_RS00190 42222..43634 + 1413 WP_156227233.1 argininosuccinate lyase -
GM160_RS00195 43682..44212 - 531 WP_156227235.1 hypothetical protein -
GM160_RS00200 44576..45202 - 627 WP_156227237.1 alpha/beta fold hydrolase -
GM160_RS00205 45283..45930 + 648 WP_156227239.1 pyridoxamine 5'-phosphate oxidase -
GM160_RS00210 45927..46649 + 723 WP_156227241.1 uracil-DNA glycosylase -
GM160_RS00215 46891..47634 - 744 WP_156575280.1 RES family NAD+ phosphorylase Toxin
GM160_RS00220 47647..48015 - 369 WP_156227243.1 MbcA/ParS/Xre antitoxin family protein Antitoxin
GM160_RS00225 48313..48984 - 672 WP_156227245.1 DNA repair protein RadC -
GM160_RS00230 49031..49792 - 762 WP_156227247.1 putative DNA-binding domain-containing protein -
GM160_RS00235 49792..50649 - 858 WP_156227249.1 DUF692 domain-containing protein -
GM160_RS00240 50785..51024 - 240 WP_136868030.1 hypothetical protein -
GM160_RS00245 51222..51827 - 606 WP_156227251.1 thioredoxin family protein -
GM160_RS00250 52028..52996 + 969 WP_156227253.1 hydroxymethylbilane synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(61-202)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(12-49)


Sequences

Toxin        


Download         Length: 248 a.a.        Molecular weight: 27570.14 Da        Isoelectric Point: 5.7450

>T144225 WP_156575280.1 NZ_CP046415:c47634-46891 [Guyparkeria halophila]
MWQECELAERLEPIGGVLTRIVESQEQVATTGLVDTLEEQSVLEEMLEATKPPPRPGSEDLHYLLLTPFRYPPLRHGSRF
GGRFEPSLLYGSLTTDTALAEAAYYRLVFWSGMQTPPSSPLRSRHTLFRARYGTDGGLRLHRPPCDRKRPVLTDPADYAA
TQQLGRTMREAGIRGFESPSARDPNGGINVGLFEPSALTSRSPTEWEGWLCEVTGERVTFLQLTGGRIERFPADTFRVNG
QLPQPAV

Download         Length: 744 bp

>T144225 NZ_CP061779:c6149115-6148834 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13243.40 Da        Isoelectric Point: 10.4538

>AT144225 WP_156227243.1 NZ_CP046415:c48015-47647 [Guyparkeria halophila]
MTLAVAPNNASKNKAMVLAKALFNAGRGLGLSQTRIGRIVGKNRSTITRSGVDPESQNGQLALLLVRCYRSLYALMDGDE
AQMKHWMHTPNRHTGGIPAEQMLSVVGLVHVCDYLDAIRGKV

Download         Length: 369 bp

>AT144225 NZ_CP061779:c6149339-6149112 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCGTATCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACACCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References