144223

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 2271938..2273286 Replicon chromosome
Accession NZ_CP046411
Organism Vibrio parahaemolyticus strain 19-021-D1

Toxin (Protein)


Gene name sanaT Uniprot ID -
Locus tag GNY17_RS11675 Protein ID WP_156216669.1
Coordinates 2272345..2273286 (+) Length 314 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID A0A1R4LDG5
Locus tag GNY17_RS11670 Protein ID WP_000127617.1
Coordinates 2271938..2272342 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNY17_RS11655 2269759..2271102 + 1344 WP_156216666.1 tyrosine-type recombinase/integrase -
GNY17_RS11660 2271095..2271478 + 384 WP_156216668.1 hypothetical protein -
GNY17_RS11665 2271488..2271676 + 189 WP_000342585.1 hypothetical protein -
GNY17_RS11670 2271938..2272342 + 405 WP_000127617.1 hypothetical protein Antitoxin
GNY17_RS11675 2272345..2273286 + 942 WP_156216669.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
GNY17_RS11680 2273295..2273861 + 567 Protein_2151 SAM-dependent DNA methyltransferase -
GNY17_RS11685 2273933..2274208 - 276 WP_156216623.1 hypothetical protein -
GNY17_RS11690 2274512..2274724 + 213 WP_033929743.1 helix-turn-helix domain-containing protein -
GNY17_RS11695 2274763..2275875 - 1113 WP_156216625.1 hypothetical protein -
GNY17_RS11700 2275875..2276471 - 597 WP_107111805.1 pancortin-3 -
GNY17_RS11705 2276497..2277213 - 717 WP_196952916.1 M48 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2263153..2310774 47621


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(33-300)

Antitoxin

Protein of unknown function DUF6088

(8-130)


Sequences

Toxin        


Download         Length: 314 a.a.        Molecular weight: 35852.35 Da        Isoelectric Point: 5.8951

>T144223 WP_156216669.1 NZ_CP046411:2272345-2273286 [Vibrio parahaemolyticus]
MKKLKQQFLEVSDALALGNPAIIEKDYWVVALLAELETLSVETHKLVFSGGTALAKSDVKILRMSEDVDIKLIPSQEFVV
LSRGKKKALRKALVEQIEARIGQSGHFAIEDKLVRDEYRYVEYELKYPQQFSQAPCLRPIIKLELMETISLHAIEERSIQ
SLVSELYQQSREVNAFACVSIQATLVEKVLSMLRRTMLVKRDSERNDDATLVRHIYDVHCIDIAEKTTSETLAPLFHTVL
QEDIQRFGNQHAEFVADPVNELNLGLQELESNPLFRQRFDDFVKPMVFNPQPHDFDTCFASFKRIAKSLITTI

Download         Length: 942 bp

>T144223 NZ_CP061779:c3811474-3810719 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATATCCGACCGCTCCAGGGGCGCCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGAAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 15292.58 Da        Isoelectric Point: 10.3464

>AT144223 WP_000127617.1 NZ_CP046411:2271938-2272342 [Vibrio parahaemolyticus]
MTAVECIYQKIKRSRRYVFERKDFDDVASYDQVGRALRQLVKQGDLIKIGYGLYTKAKLNSLTGKPMPTHPGGTDALMRE
ILKMKGVDFEMDSLSWQSLSGQSTQIPSSVQYSWNPKQFNRKLVVGNRVLNSQN

Download         Length: 405 bp

>AT144223 NZ_CP061779:c3811977-3811609 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGAGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1R4LDG5

References