Detailed information of TA system TA144222

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 152284..152829
• Replicon: chromosome
• Accession: NZ_CP046411
• Organism: Vibrio parahaemolyticus strain 19-021-D1

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: GNY17_RS01340
• Protein ID: WP_025793277.1
• Coordinates: 152284..152580 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: Q7MKD6
• Locus tag: GNY17_RS01345
• Protein ID: WP_000557294.1
• Coordinates: 152587..152829 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNY17_RS01295	147573..147701	+	129	WP_077672984.1	DUF3265 domain-containing protein	-
GNY17_RS01300	147730..148386	+	657	WP_025793281.1	hypothetical protein	-
GNY17_RS01305	148526..149329	+	804	WP_025793280.1	hypothetical protein	-
GNY17_RS01310	149319..149411	+	93	WP_079725826.1	DUF3265 domain-containing protein	-
GNY17_RS01315	149438..150070	+	633	WP_025793279.1	hypothetical protein	-
GNY17_RS01320	150217..150519	+	303	WP_025537048.1	hypothetical protein	-
GNY17_RS27795	150459..150626	+	168	WP_001883086.1	DUF3265 domain-containing protein	-
GNY17_RS01330	150657..151178	+	522	WP_015296898.1	GNAT family N-acetyltransferase	-
GNY17_RS01335	151308..151646	+	339	WP_196952914.1	cupin domain-containing protein	-
GNY17_RS01340	152284..152580	-	297	WP_025793277.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GNY17_RS01345	152587..152829	-	243	WP_000557294.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
GNY17_RS01350	153119..153340	+	222	Protein_251	transposase	-
GNY17_RS01355	153382..154260	+	879	WP_140142865.1	IS3 family transposase	-
GNY17_RS01365	154493..154548	+	56	Protein_253	DUF3265 domain-containing protein	-
GNY17_RS01370	154735..155625	+	891	WP_005485669.1	hypothetical protein	-
GNY17_RS01375	155706..156116	+	411	WP_024701711.1	hypothetical protein	-
GNY17_RS01380	156295..156729	+	435	Protein_256	GNAT family N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	157035..157421	386
	-	inside	Integron	-	-	34290..156591	122301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-50)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11249.00 Da
• Isoelectric Point: 9.8450

>T144222 WP_025793277.1 NZ_CP046411:c152580-152284 [Vibrio parahaemolyticus]
MQKNKYKLSKLAQAHLRKIKSYTVNNFSEMQWRSYKDTLLTGFQMLADNPAVGRSCDEIYPSGFYFPVGKHTAYFTKEDG
FILVVAILGQSLLPQNHL

Nucleotide

• Length: 297 bp

>T144222 NZ_CP061779:2877080-2877658 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8973.13 Da
• Isoelectric Point: 4.6135

>AT144222 WP_000557294.1 NZ_CP046411:c152829-152587 [Vibrio parahaemolyticus]
MHTLTANDAKRNFGELLLSAQREPVKISKNSKDAVVVMSIKDYEELEAMKADYLRHCFESAKQDLAQGDVVDGEDFLNAL

Nucleotide

• Length: 243 bp

>AT144222 NZ_CP061779:2876437-2876991 [Pseudomonas aeruginosa]
ATGACCGAGCCTCTCCCTTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGTTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGATG
AACTCGGCTGGCGCGAACTGCTGGCACCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTCTCGGACGGACGCGCGGTGCGCCTGGTGGAAACCCTCTGA

Structures

Antitoxin

• AlphaFold DB: Q7MKD6