Detailed information of TA system TA144218

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 48701..49260
• Replicon: chromosome
• Accession: NZ_CP046411
• Organism: Vibrio parahaemolyticus strain 19-021-D1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GNY17_RS00320
• Protein ID: WP_025793444.1
• Coordinates: 48701..48979 (-)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U2ZGZ5
• Locus tag: GNY17_RS00325
• Protein ID: WP_005497249.1
• Coordinates: 48976..49260 (-)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNY17_RS00255	43851..44222	+	372	WP_025793440.1	RidA family protein	-
GNY17_RS00260	44219..44359	+	141	WP_148299773.1	DUF3265 domain-containing protein	-
GNY17_RS00265	44368..45030	+	663	WP_025793441.1	hypothetical protein	-
GNY17_RS00270	45051..45143	+	93	WP_080277533.1	DUF3265 domain-containing protein	-
GNY17_RS00275	45177..45551	+	375	WP_025793442.1	hypothetical protein	-
GNY17_RS00280	45538..45657	+	120	WP_080277534.1	DUF3265 domain-containing protein	-
GNY17_RS00285	45741..46106	+	366	WP_025793443.1	hypothetical protein	-
GNY17_RS00290	46593..46685	+	93	WP_140050476.1	DUF3265 domain-containing protein	-
GNY17_RS00305	47782..47913	+	132	WP_080277536.1	DUF3265 domain-containing protein	-
GNY17_RS00310	47995..48252	+	258	WP_005448240.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
GNY17_RS00315	48240..48542	+	303	WP_025548916.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GNY17_RS00320	48701..48979	-	279	WP_025793444.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
GNY17_RS00325	48976..49260	-	285	WP_005497249.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GNY17_RS00330	50596..51018	+	423	Protein_59	GFA family protein	-
GNY17_RS00335	51052..51141	+	90	WP_077281693.1	DUF3265 domain-containing protein	-
GNY17_RS00340	51730..52032	-	303	WP_025793446.1	hypothetical protein	-
GNY17_RS00345	52106..52198	+	93	WP_080261757.1	DUF3265 domain-containing protein	-
GNY17_RS00350	52240..52506	+	267	WP_025793447.1	barstar family protein	-
GNY17_RS00355	52684..53286	+	603	WP_033904997.1	hypothetical protein	-
GNY17_RS00360	53404..54141	+	738	WP_025793449.1	hypothetical protein	-
GNY17_RS00365	54170..54247	+	78	WP_080277538.1	DUF3265 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	34290..156591	122301

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-89)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (5-69)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10930.57 Da
• Isoelectric Point: 4.3697

>T144218 WP_025793444.1 NZ_CP046411:c48979-48701 [Vibrio parahaemolyticus]
MILWEEESLNDREKIFEFLYDFNPEAADKTDDIIEAKVENLLEQPHMGVQRDGIRGRLLIIPEISMIVSYWVEGDIIRIM
RVLHQKQKFPTD

Nucleotide

• Length: 279 bp

>T144218 NZ_CP061779:654661-655530 [Pseudomonas aeruginosa]
ATGAACATGGCGCAGACCCACATCCCCGCCCCGAGCCTGCAACAGCGCTTTCCCGAGCGGCTGGTGCAACTGGCCGACGG
CGCCCAGTTGGCCATCCGCGAATGCGGCCAGGGCCCGGTGGTGGTGCTGTTGCACGGCATCGGTTCGGGCTCGGCGTCCT
GGCTGCATTGCGCCCAGCGCCTGGCCGCCGGCAATCGGGTGATCGCCTGGGACGCGCCGGGCTACGGCCTGTCCACGCCG
CTGCCGCCGGCCCGGCCCAAGGCCTGCGACTACGCCGCGTGCCTGGAGCTGCTGCTGGATGCGCTGGGCGTGGAGAGCTG
CCTGCTGGTGGGCCACTCCCTCGGCGCGCTGATGGCCACGGCCTACGCCGCCGGCATCGGCGCGGCGCGGGTGCGTCGCC
TGGTACTGCTCAGCCCGGCGCGCGGCTACGGCGCCGCCGAGCTGCGCGACAGCGGCGCCCAGGTGCGCCGCCAGCGCCTG
GAGAACCTGGAGCGCCTCGGCATCGACGGCATGGCCAGCGAGCGCACCGCGCGCCTGCTCGGCCGCAACCCCAGCGAGGA
GGCCCTGGCCTGGGTGCGCTGGAACATGGCGCGGCTCAACCCCGAGGGCTACCGCCAGGCCGTCGAGCTGCTCTGCGGCG
ACGACCTGCTGGGCAACGGGCAGCCTGCCGCTCCTTGCGAGGTGCATTGCGGCGAGGACGACGGCATCACCACGCCCGAG
AGTTGCGGCGCCATCGCCCGCCAGCTCGGCGCGTCGTTCTCGCCGATTCCCGGGGCCGGCCACGCCAGCCCGATCGAACA
ACCCGAAGTGGTCGCAGGACGCATCGGCCACGCGCAACGCCTCTCTCTTGAAGGAACCGCCAATGGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10913.25 Da
• Isoelectric Point: 9.1865

>AT144218 WP_005497249.1 NZ_CP046411:c49260-48976 [Vibrio parahaemolyticus]
MDTRIQFRVDEETKRLAQQMAESQGRTLSDACRELTEQLADQQRKTLSHDAWLTEQVNLAFEKFDSGKATFVDHESAKSR
MAERKAKIRNRGKL

Nucleotide

• Length: 285 bp

>AT144218 NZ_CP061779:655523-656356 [Pseudomonas aeruginosa]
ATGGATAAGTCAGACGATTCGCAAGACAAGTACATCGTGCCTGGCCTCGAACGCGGCCTGCTGCTGCTCTGCGAGTTCAG
CCGGAAGGACCGTACCCTGACGGCGCCGGAGTTGGCGCGGCGCCTGAAGCTGCCGCGCTCGACCATCTTCCGCCTGCTGA
CCACCCTGGAGGCCATGGGCTTCGTCACCCGCAACGGCAACGAGTACCGCCTGGGCATGGCGGTGTTGCGCCTGGGCTTC
GAGTACCTGGCCTCGCTGGAGCTGACCGAACTCGGCCAGCCGCTGCTGAACCGCCTGTGCGACGAGATCCGCTACCCCTG
CAACCTGGTGGTGCGCGACGGCCGTTCGATCGTCTACGTGGCCAAGGTCTCGCCGTCCACCCCGCTGAGCAGCTCGGTGA
ACGTCGGGACCCGGTTGCCGGCCCACGCCACGGTGCTCGGCCGCATCCTGCTGCAGGACCTGAGCCTGGGCGAGCTGCGC
GAGCTGTACCCGGAGGAGCAGCTGGAGCAGTTCTCGCCGAACACCCCGCGCAGCGTGCTGGAACTCTTCGACATGGTCCA
GGGCGACCGCCAGCGTGGCTTCGTCCAGGGCGAGGGGTTCTTCGAGGCGAGCATCTCCACCGTCGCGGCGCCGGTACGTG
ATCACAGCGGTCGCGTCATCGCGGCGATGGGGGCGACCATCGCCGCCGGGCATATCGACCCGGAACGCATCGAGGGACTG
GTCAGCCGGGTGCGCAGCAGCGCCGACGAGCTGTCGTACCTGCTCGACTACCGCGCCGACGGCCAGGACAACGTCACCCC
GATCTTCCGGAGTCGCCCGCATGAAACCGTATGA

Structures

Antitoxin

• AlphaFold DB: U2ZGZ5