144217

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Phd(antitoxin)
Location 47995..48542 Replicon chromosome
Accession NZ_CP046411
Organism Vibrio parahaemolyticus strain 19-021-D1

Toxin (Protein)


Gene name relE Uniprot ID A0A347UR19
Locus tag GNY17_RS00315 Protein ID WP_025548916.1
Coordinates 48240..48542 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U3A269
Locus tag GNY17_RS00310 Protein ID WP_005448240.1
Coordinates 47995..48252 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNY17_RS00250 43018..43737 + 720 WP_025793439.1 hypothetical protein -
GNY17_RS00255 43851..44222 + 372 WP_025793440.1 RidA family protein -
GNY17_RS00260 44219..44359 + 141 WP_148299773.1 DUF3265 domain-containing protein -
GNY17_RS00265 44368..45030 + 663 WP_025793441.1 hypothetical protein -
GNY17_RS00270 45051..45143 + 93 WP_080277533.1 DUF3265 domain-containing protein -
GNY17_RS00275 45177..45551 + 375 WP_025793442.1 hypothetical protein -
GNY17_RS00280 45538..45657 + 120 WP_080277534.1 DUF3265 domain-containing protein -
GNY17_RS00285 45741..46106 + 366 WP_025793443.1 hypothetical protein -
GNY17_RS00290 46593..46685 + 93 WP_140050476.1 DUF3265 domain-containing protein -
GNY17_RS00305 47782..47913 + 132 WP_080277536.1 DUF3265 domain-containing protein -
GNY17_RS00310 47995..48252 + 258 WP_005448240.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GNY17_RS00315 48240..48542 + 303 WP_025548916.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GNY17_RS00320 48701..48979 - 279 WP_025793444.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family -
GNY17_RS00325 48976..49260 - 285 WP_005497249.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
GNY17_RS00330 50596..51018 + 423 Protein_59 GFA family protein -
GNY17_RS00335 51052..51141 + 90 WP_077281693.1 DUF3265 domain-containing protein -
GNY17_RS00340 51730..52032 - 303 WP_025793446.1 hypothetical protein -
GNY17_RS00345 52106..52198 + 93 WP_080261757.1 DUF3265 domain-containing protein -
GNY17_RS00350 52240..52506 + 267 WP_025793447.1 barstar family protein -
GNY17_RS00355 52684..53286 + 603 WP_033904997.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integron - - 34290..156591 122301


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-69)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11669.57 Da        Isoelectric Point: 5.1765

>T144217 WP_025548916.1 NZ_CP046411:48240-48542 [Vibrio parahaemolyticus]
MAEIIWTEPALSDLNDIAEYIALENIVAAKQLVQTIFSKVERLQTFPESGRIPPELEHLSYREVVVNPCRVFYKQDGDKV
FILFVMRAERDLRKFLLSKQ

Download         Length: 303 bp

>T144217 NZ_CP061778:c6689119-6688772 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCACTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9606.10 Da        Isoelectric Point: 6.7269

>AT144217 WP_005448240.1 NZ_CP046411:47995-48252 [Vibrio parahaemolyticus]
MKVELVTSLKRQATKILADLHDTKEPVLITEHGKPSAYLVDVDDYEFMQNRLAILEGIARGERALADGKVVSHDEAKDKM
SKWLK

Download         Length: 258 bp

>AT144217 NZ_CP061778:c6689380-6689129 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A347UR19

Antitoxin

Source ID Structure
AlphaFold DB A0A432DGX8

References