144203

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 5094145..5094753 Replicon chromosome
Accession NZ_CP046404
Organism Pseudomonas aeruginosa strain SE5416

Toxin (Protein)


Gene name PfiT Uniprot ID A0A444LUU5
Locus tag GNT55_RS23990 Protein ID WP_019486378.1
Coordinates 5094145..5094492 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag GNT55_RS23995 Protein ID WP_003114155.1
Coordinates 5094502..5094753 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNT55_RS23970 5090644..5091075 + 432 WP_031632963.1 hypothetical protein -
GNT55_RS23975 5091983..5092300 + 318 Protein_4746 hypothetical protein -
GNT55_RS23980 5092412..5092618 + 207 WP_071534345.1 AlpA family phage regulatory protein -
GNT55_RS23985 5092624..5093826 - 1203 WP_028680753.1 integrase family protein -
GNT55_RS23990 5094145..5094492 - 348 WP_019486378.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GNT55_RS23995 5094502..5094753 - 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
GNT55_RS24000 5094967..5095950 - 984 WP_003114154.1 tyrosine-type recombinase/integrase -
GNT55_RS24005 5095950..5097242 - 1293 WP_003115206.1 hypothetical protein -
GNT55_RS24010 5097472..5098746 - 1275 WP_179063290.1 zonular occludens toxin family protein -
GNT55_RS24015 5098750..5099106 - 357 WP_003114150.1 DUF2523 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 5052393..5108343 55950


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12956.72 Da        Isoelectric Point: 4.4212

>T144203 WP_019486378.1 NZ_CP046404:c5094492-5094145 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T144203 NZ_CP061777:2359691-2359972 [Pseudomonas aeruginosa]
ATGACCTATAAGCTCGAGTTCCTGCCCTCAGCGCTGAAGGAATGGGAGAAGCTGGGTCATACGGTGCGTGAGCAGGCAAA
GAAAAAACTGCGTGAGCGGCTGGAAGCACCAAAGGTACAGGCTGATGCCCTCAGGGATCTGCCTGGCCACTACAAGATCA
AGCTCCGAACAGCAGGCTATCGATTGGTCTATAATGTCGAGGATGATCGGGTGGTTGTGATTGTGGTCGCAGTGGGCAAG
CGTGAACGAAGTGCAGCTTACAAGGCAGCAGGTAAGCGTTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT144203 WP_003114155.1 NZ_CP046404:c5094753-5094502 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT144203 NZ_CP061777:2359456-2359701 [Pseudomonas aeruginosa]
ATGCAGAGTGTTTTGGCTGACGTTGCCGTGAGCGTTTCTGAGCTGAAGAAAAACCCCACCGGTGTCATGGCTGGTGCGGG
TGGCATGCCGGTCGCAGTTCTCAATCATAACCGCGTGATGGGGTACATGGTGCCAGCCGAGCTGTACGAGCAGATGTTGG
ACCGTTTGGACGATCTGGATCTGATCGATGTCGTTAACGCGCGCTCCGGTGAGAAGGGTGTGCCGGTGAACCTGGATGAC
CTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A444LUU5

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References