Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4703957..4704751 Replicon chromosome
Accession NZ_CP046404
Organism Pseudomonas aeruginosa strain SE5416

Toxin (Protein)


Gene name hicA Uniprot ID A0A844NUK8
Locus tag GNT55_RS21990 Protein ID WP_021263385.1
Coordinates 4703957..4704136 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag GNT55_RS21995 Protein ID WP_021263386.1
Coordinates 4704176..4704751 (+) Length 192 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNT55_RS21960 4699599..4700954 - 1356 WP_021263382.1 DUF4055 domain-containing protein -
GNT55_RS21965 4700957..4702252 - 1296 WP_021263383.1 terminase family protein -
GNT55_RS21970 4702239..4702835 - 597 WP_021263384.1 terminase small subunit -
GNT55_RS21975 4702844..4703128 - 285 WP_016852757.1 phage holin family protein -
GNT55_RS21980 4703121..4703510 - 390 WP_004349441.1 hypothetical protein -
GNT55_RS21985 4703653..4703868 - 216 WP_019486654.1 hypothetical protein -
GNT55_RS21990 4703957..4704136 + 180 WP_021263385.1 type II toxin-antitoxin system HicA family toxin Toxin
GNT55_RS21995 4704176..4704751 + 576 WP_021263386.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GNT55_RS22000 4704842..4705711 - 870 WP_021263387.1 hypothetical protein -
GNT55_RS22005 4705740..4706183 - 444 WP_021263388.1 RusA family crossover junction endodeoxyribonuclease -
GNT55_RS22010 4706176..4706784 - 609 WP_021263389.1 hypothetical protein -
GNT55_RS22015 4707248..4707718 - 471 Protein_4362 hypothetical protein -
GNT55_RS22020 4707721..4708293 - 573 WP_019682191.1 hypothetical protein -
GNT55_RS22025 4708325..4708543 - 219 WP_016561979.1 helix-turn-helix domain-containing protein -
GNT55_RS22030 4708921..4709493 + 573 WP_023088260.1 S24 family peptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6591.62 Da        Isoelectric Point: 11.1475

>T144202 WP_021263385.1 NZ_CP046404:4703957-4704136 [Pseudomonas aeruginosa]
MKFSEFRRWLRAQGVSFEAGKGSHFKVTAPNGKTTTFADHGAKEMPEPTRKAIIKQLGL

Download         Length: 180 bp

>T144202 NZ_CP061777:1668562-1669149 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
AGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 192 a.a.        Molecular weight: 21294.78 Da        Isoelectric Point: 8.3556

>AT144202 WP_021263386.1 NZ_CP046404:4704176-4704751 [Pseudomonas aeruginosa]
MYNFAIRFEQDDSAPGVAVFCRDLPELNSYGDTVEHALSEAVDAIETTLSLYVDQRRSIPVASAPEPEEHVVHLPAVTVA
KIALWNEMMRRGMRKADLCRVLGIAQVQGDRLVDFLHTSKMEQVESALAALEMRLVICAEPVKQPKQCKGAGCIRDRRLV
KARRLLRARLLELTESSGAFTRAPKIKKPGI

Download         Length: 576 bp

>AT144202 NZ_CP061777:1669216-1670070 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTGGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAGATGGAGCAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGTGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCATCCTTGACGATCTACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A844NUK8

Antitoxin

Source ID Structure

References