Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 3230031..3231073 | Replicon | chromosome |
| Accession | NZ_CP046404 | ||
| Organism | Pseudomonas aeruginosa strain SE5416 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | GNT55_RS15310 | Protein ID | WP_003153636.1 |
| Coordinates | 3230498..3231073 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | GNT55_RS15305 | Protein ID | WP_003050245.1 |
| Coordinates | 3230031..3230501 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| GNT55_RS15270 | 3225423..3226841 | - | 1419 | WP_004350605.1 | TIGR03752 family integrating conjugative element protein | - |
| GNT55_RS15275 | 3226831..3227742 | - | 912 | WP_004350604.1 | TIGR03749 family integrating conjugative element protein | - |
| GNT55_RS15280 | 3227739..3228431 | - | 693 | WP_004350603.1 | TIGR03746 family integrating conjugative element protein | - |
| GNT55_RS15285 | 3228428..3228826 | - | 399 | WP_003153632.1 | TIGR03750 family conjugal transfer protein | - |
| GNT55_RS15290 | 3228838..3229197 | - | 360 | WP_012248080.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| GNT55_RS15295 | 3229214..3229447 | - | 234 | WP_053817027.1 | TIGR03758 family integrating conjugative element protein | - |
| GNT55_RS15300 | 3229444..3229827 | - | 384 | WP_053817028.1 | RAQPRD family integrative conjugative element protein | - |
| GNT55_RS15305 | 3230031..3230501 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| GNT55_RS15310 | 3230498..3231073 | + | 576 | WP_003153636.1 | PIN domain-containing protein | Toxin |
| GNT55_RS15315 | 3231091..3232005 | + | 915 | WP_003050256.1 | AAA family ATPase | - |
| GNT55_RS15320 | 3232002..3232472 | + | 471 | WP_053817029.1 | hypothetical protein | - |
| GNT55_RS15325 | 3232469..3232969 | + | 501 | WP_003090159.1 | hypothetical protein | - |
| GNT55_RS15330 | 3232969..3233871 | + | 903 | WP_053817030.1 | nucleotidyltransferase domain-containing protein | - |
| GNT55_RS15335 | 3233910..3234635 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 3175632..3280601 | 104969 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21629.78 Da Isoelectric Point: 5.9995
>T144200 WP_003153636.1 NZ_CP046404:3230498-3231073 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPNDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIDVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T144200 NZ_CP061771:3566727-3567125 [Salinibacterium sp. ZJ450]
ATGATCGTCGACTCCTCTGCGCTGATCGCCATTGCGCGCCAGGAACCGGACGCTGCAACCTACGCTCGGGCGCTGGCCCG
GTCGGAGGCAAGCTTCCTGTCGGCGGCGAACTACGTCGAGGCGGCGATCGTGGTCGACCGCTCCCACGACCCGATCGCGA
GCCGGGCATTCGATGACCTCCTGAGCCTGGCCTCGATCAGAATCGAACCGGTCACCGTCGAACAGGCGCGTATTGCTCGC
GATGCGTATCGCGATTTCGGCGAGGGCAGTGGACATCCGGCCGGTCTCAACTTCGGCGACTGTTTCGCCTACGCCCTCGC
CAAGGACCGCGGACAGCCCCTTCTTTTCAAGGGCGATGACTTCTCACAGACCGACGTGCAGAGCGCACTGGACAGCTGA
ATGATCGTCGACTCCTCTGCGCTGATCGCCATTGCGCGCCAGGAACCGGACGCTGCAACCTACGCTCGGGCGCTGGCCCG
GTCGGAGGCAAGCTTCCTGTCGGCGGCGAACTACGTCGAGGCGGCGATCGTGGTCGACCGCTCCCACGACCCGATCGCGA
GCCGGGCATTCGATGACCTCCTGAGCCTGGCCTCGATCAGAATCGAACCGGTCACCGTCGAACAGGCGCGTATTGCTCGC
GATGCGTATCGCGATTTCGGCGAGGGCAGTGGACATCCGGCCGGTCTCAACTTCGGCGACTGTTTCGCCTACGCCCTCGC
CAAGGACCGCGGACAGCCCCTTCTTTTCAAGGGCGATGACTTCTCACAGACCGACGTGCAGAGCGCACTGGACAGCTGA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT144200 WP_003050245.1 NZ_CP046404:3230031-3230501 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT144200 NZ_CP061771:3566545-3566730 [Salinibacterium sp. ZJ450]
GTGAGCCAAACCCGCGCCGTAGAAGACGCTGTCAACCGCCGCCTCGACGAATTGAGGCGACACGCGCCCGAGGACAAGGC
CGAGCGCATTCTCGCGGTCGGCCGGGAGATCGCGGGCCGACTCGGGCCCGACAGTTTCGGCGATGTCGACGACCTGCTCT
ATGACGAACACGGGCTGCCTCGATGA
GTGAGCCAAACCCGCGCCGTAGAAGACGCTGTCAACCGCCGCCTCGACGAATTGAGGCGACACGCGCCCGAGGACAAGGC
CGAGCGCATTCTCGCGGTCGGCCGGGAGATCGCGGGCCGACTCGGGCCCGACAGTTTCGGCGATGTCGACGACCTGCTCT
ATGACGAACACGGGCTGCCTCGATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|