Detailed information of TA system TA144199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2461775..2463033
• Replicon: chromosome
• Accession: NZ_CP046404
• Organism: Pseudomonas aeruginosa strain SE5416

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: GNT55_RS11710
• Protein ID: WP_028681273.1
• Coordinates: 2462278..2463033 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: GNT55_RS11705
• Protein ID: WP_028681272.1
• Coordinates: 2461775..2462143 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNT55_RS11685	2457938..2458213	+	276	WP_010792073.1	zinc ribbon domain-containing protein	-
GNT55_RS11690	2458216..2458692	-	477	WP_003112531.1	hypothetical protein	-
GNT55_RS11695	2458771..2460360	+	1590	WP_003123191.1	aldehyde dehydrogenase family protein	-
GNT55_RS11700	2460416..2461702	+	1287	WP_003163134.1	FAD-binding oxidoreductase	-
GNT55_RS11705	2461775..2462143	+	369	WP_028681272.1	DUF2384 domain-containing protein	Antitoxin
GNT55_RS11710	2462278..2463033	+	756	WP_028681273.1	RES family NAD+ phosphorylase	Toxin
GNT55_RS11715	2463803..2465164	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
GNT55_RS11720	2465319..2467862	-	2544	WP_028681274.1	acyl-homoserine-lactone acylase QuiP	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28262.43 Da
• Isoelectric Point: 7.7294

>T144199 WP_028681273.1 NZ_CP046404:2462278-2463033 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGAPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T144199 NZ_CP061765:84371-84787 [Escherichia coli O19:H7]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13395.68 Da
• Isoelectric Point: 10.2722

>AT144199 WP_028681272.1 NZ_CP046404:2461775-2462143 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGRVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT144199 NZ_CP061765:84144-84374 [Escherichia coli O19:H7]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA