Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 4065444..4066665 Replicon chromosome
Accession NZ_CP046403
Organism Pseudomonas aeruginosa strain SE5369

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag GNT46_RS19075 Protein ID WP_003114949.1
Coordinates 4066087..4066665 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag GNT46_RS19070 Protein ID WP_003088112.1
Coordinates 4065444..4065998 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNT46_RS19045 4061012..4061563 + 552 WP_003102727.1 XRE family transcriptional regulator -
GNT46_RS19050 4061560..4061958 - 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
GNT46_RS19055 4061971..4062294 - 324 WP_003102734.1 multidrug efflux SMR transporter -
GNT46_RS19060 4062625..4063086 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
GNT46_RS19065 4063091..4065286 + 2196 WP_023082959.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
GNT46_RS19070 4065444..4065998 + 555 WP_003088112.1 helix-turn-helix domain-containing protein Antitoxin
GNT46_RS19075 4066087..4066665 + 579 WP_003114949.1 HD domain-containing protein Toxin
GNT46_RS19080 4066773..4067960 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
GNT46_RS19085 4067950..4070121 - 2172 WP_003088105.1 type I secretion system permease/ATPase -
GNT46_RS19090 4070111..4071388 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T144193 WP_003114949.1 NZ_CP046403:4066087-4066665 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T144193 NZ_CP061764:2897646-2897753 [Escherichia coli O19:H7]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTACTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT144193 WP_003088112.1 NZ_CP046403:4065444-4065998 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT144193 NZ_CP061764:c2897596-2897533 [Escherichia coli O19:H7]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References