Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 153228..153733 Replicon chromosome
Accession NZ_CP046403
Organism Pseudomonas aeruginosa strain SE5369

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag GNT46_RS00695 Protein ID WP_003121619.1
Coordinates 153228..153509 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag GNT46_RS00700 Protein ID WP_003083775.1
Coordinates 153506..153733 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GNT46_RS00670 148479..149828 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
GNT46_RS00675 149877..150563 + 687 WP_003083762.1 FadR family transcriptional regulator -
GNT46_RS00680 150664..151398 + 735 WP_003117208.1 GntR family transcriptional regulator -
GNT46_RS00685 151602..151988 + 387 WP_014602345.1 aegerolysin family protein -
GNT46_RS00690 152020..152928 - 909 WP_023083551.1 LysR family transcriptional regulator -
GNT46_RS00695 153228..153509 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
GNT46_RS00700 153506..153733 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
GNT46_RS00705 153909..154529 - 621 WP_003101226.1 hypothetical protein -
GNT46_RS00710 154630..155130 + 501 WP_003101228.1 LEA type 2 family protein -
GNT46_RS00715 155203..155544 + 342 WP_003101229.1 alkylphosphonate utilization protein -
GNT46_RS00720 155626..157053 - 1428 WP_003083784.1 GABA permease -
GNT46_RS00725 157222..158715 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T144189 WP_003121619.1 NZ_CP046403:c153509-153228 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T144189 NZ_CP061764:2162595-2162698 [Escherichia coli O19:H7]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT144189 WP_003083775.1 NZ_CP046403:c153733-153506 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT144189 NZ_CP061764:c2162736-2162465 [Escherichia coli O19:H7]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References