Detailed information of TA system TA144183

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 183634..184139
• Replicon: chromosome
• Accession: NZ_CP046402
• Organism: Pseudomonas aeruginosa strain SE5331

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: GNT44_RS00800
• Protein ID: WP_003083773.1
• Coordinates: 183634..183915 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: GNT44_RS00805
• Protein ID: WP_003083775.1
• Coordinates: 183912..184139 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GNT44_RS00775	178885..180234	+	1350	WP_003137006.1	C4-dicarboxylate transporter DctA	-
GNT44_RS00780	180283..180969	+	687	WP_003083762.1	FadR family transcriptional regulator	-
GNT44_RS00785	181070..181804	+	735	WP_003083764.1	GntR family transcriptional regulator	-
GNT44_RS00790	182008..182394	+	387	WP_003083767.1	aegerolysin family protein	-
GNT44_RS00795	182426..183334	-	909	WP_003083769.1	LysR family transcriptional regulator	-
GNT44_RS00800	183634..183915	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
GNT44_RS00805	183912..184139	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
GNT44_RS00810	184315..184935	-	621	WP_003101226.1	hypothetical protein	-
GNT44_RS00815	185036..185536	+	501	WP_003083778.1	LEA type 2 family protein	-
GNT44_RS00820	185609..185950	+	342	WP_014603467.1	alkylphosphonate utilization protein	-
GNT44_RS00825	186032..187459	-	1428	WP_003083784.1	GABA permease	-
GNT44_RS00830	187628..189121	-	1494	WP_003083788.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T144183 WP_003083773.1 NZ_CP046402:c183915-183634 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T144183 NZ_CP061764:797239-797535 [Escherichia coli O19:H7]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT144183 WP_003083775.1 NZ_CP046402:c184139-183912 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT144183 NZ_CP061764:797537-797932 [Escherichia coli O19:H7]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACACAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9