Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 2285812..2286790 Replicon chromosome
Accession NZ_CP046398
Organism Bacillus sp. A260

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag GD442_RS11670 Protein ID WP_000624977.1
Coordinates 2285812..2286549 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID M1PKC2
Locus tag GD442_RS11675 Protein ID WP_000237819.1
Coordinates 2286662..2286790 (+) Length 43 a.a.

Genomic Context

GD442_RS11645GD442_RS11650GD442_RS11660GD442_RS11665GD442_RS11670GD442_RS11675GD442_RS11680GD442_RS11690GD442_RS11695GD442_RS11700GD442_RS11655GD442_RS11685
Location: 2281425..2281832 (408 bp)
Type: Others
Protein ID: WP_000072495.1
Location: 2281856..2282236 (381 bp)
Type: Others
Protein ID: WP_000497668.1
Location: 2284187..2284669 (483 bp)
Type: Others
Protein ID: WP_000191885.1
Location: 2284836..2285573 (738 bp)
Type: Others
Protein ID: WP_000594152.1
Location: 2285812..2286549 (738 bp)
Type: Toxin
Protein ID: WP_000624977.1
Location: 2286662..2286790 (129 bp)
Type: Antitoxin
Protein ID: WP_000237819.1
Location: 2286863..2287039 (177 bp)
Type: Others
Protein ID: WP_000852629.1
Location: 2287656..2289125 (1470 bp)
Type: Others
Protein ID: WP_000287546.1
Location: 2289371..2290180 (810 bp)
Type: Others
Protein ID: WP_000664544.1
Location: 2290206..2290808 (603 bp)
Type: Others
Protein ID: WP_000517259.1
Location: 2282394..2284079 (1686 bp)
Type: Others
Protein ID: WP_002041140.1
Location: 2287055..2287444 (390 bp)
Type: Others
Protein ID: WP_000713869.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
GD442_RS116452281425..2281832+408WP_000072495.1VOC family protein-
GD442_RS116502281856..2282236+381WP_000497668.1methyltransferase-
GD442_RS116552282394..2284079-1686WP_002041140.1alpha-keto acid decarboxylase family protein-
GD442_RS116602284187..2284669+483WP_000191885.1MarR family winged helix-turn-helix transcriptional regulator-
GD442_RS116652284836..2285573+738WP_000594152.12,3-diphosphoglycerate-dependent phosphoglycerate mutase-
GD442_RS116702285812..2286549+738WP_000624977.1stage II sporulation protein SAToxin
GD442_RS116752286662..2286790+129WP_000237819.1hypothetical proteinAntitoxin
GD442_RS116802286863..2287039+177WP_000852629.1stage II sporulation protein SB-
GD442_RS116852287055..2287444-390WP_000713869.1YxeA family protein-
GD442_RS116902287656..2289125+1470WP_000287546.1beta-Ala-His dipeptidase-
GD442_RS116952289371..2290180+810WP_000664544.1C39 family peptidase-
GD442_RS117002290206..2290808+603WP_000517259.1hypothetical protein-

Associated MGEs

Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T144181 WP_000624977.1 NZ_CP046398:2285812-2286549 [Bacillus sp. A260]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

>T144181 NZ_CP061764:c628023-627559 [Escherichia coli O19:H7]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 4953.36 Da        Isoelectric Point: 3.9798

>AT144181 WP_000237819.1 NZ_CP046398:2286662-2286790 [Bacillus sp. A260]
VVKDYDNDFFKEGNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp

>AT144181 NZ_CP061764:c628358-628023 [Escherichia coli O19:H7]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBW8Y388

Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBM1PKC2

References