Detailed information of TA system TA144150

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 2993950..2994478
• Replicon: chromosome
• Accession: NZ_CP046392
• Organism: Acinetobacter indicus strain WMB-7

Toxin (Protein)

• Gene name: relE
• Uniprot ID: N9N871
• Locus tag: GK020_RS14540
• Protein ID: WP_000221358.1
• Coordinates: 2993950..2994243 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: GK020_RS14545
• Protein ID: WP_104988060.1
• Coordinates: 2994233..2994478 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GK020_RS14515	2989253..2989816	-	564	WP_005180661.1	alkyl hydroperoxide reductase subunit C	-
GK020_RS14520	2990523..2991038	-	516	Protein_2797	IS3 family transposase	-
GK020_RS14525	2991092..2992024	+	933	WP_104988061.1	IS5 family transposase	-
GK020_RS14530	2992288..2992617	+	330	WP_004641881.1	four-helix bundle copper-binding protein	-
GK020_RS14535	2992767..2993807	-	1041	WP_016658839.1	IS481 family transposase	-
GK020_RS14540	2993950..2994243	-	294	WP_000221358.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GK020_RS14545	2994233..2994478	-	246	WP_104988060.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GK020_RS14550	2994588..2995913	-	1326	WP_001280601.1	ISNCY family transposase	-
GK020_RS14555	2996145..2997089	-	945	WP_004668309.1	copper resistance protein B	-
GK020_RS14560	2997076..2997414	-	339	WP_104988059.1	hypothetical protein	-
GK020_RS14565	2997401..2999266	-	1866	WP_104988058.1	copper resistance system multicopper oxidase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	2990523..2995925	5402

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (8-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11292.52 Da
• Isoelectric Point: 10.4753

>T144150 WP_000221358.1 NZ_CP046392:c2994243-2993950 [Acinetobacter indicus]
MTYKLLRHKDFTAEWEKLPVAIRDQFKKKLAKVIEQPHIPKNMLRGDLAGCYKIKLLKAGVRLVYQVKDDQVVILLITVG
KRADSIVYDEAKKRIKD

Nucleotide

• Length: 294 bp

>T144150 NZ_CP061754:c1951147-1950773 [Escherichia coli O18ac:H14]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACACGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9279.66 Da
• Isoelectric Point: 4.3142

>AT144150 WP_104988060.1 NZ_CP046392:c2994478-2994233 [Acinetobacter indicus]
MATVNFRIDEALKEKSYSILKEQGITPTDFFTSILEYVATTGKLPVKKALLSEEDEELLALVRKRINDPKEMFEEVTLDD
L

Nucleotide

• Length: 246 bp

>AT144150 NZ_CP061754:c1951605-1951237 [Escherichia coli O18ac:H14]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Structures

Toxin

• AlphaFold DB: A0A6A1RKP4