Detailed information of TA system TA144148

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): NpoTA/ParE(toxin)
• Location: 1609853..1610968
• Replicon: chromosome
• Accession: NZ_CP046392
• Organism: Acinetobacter indicus strain WMB-7

Toxin (Protein)

• Gene name: NpoT
• Uniprot ID: V2U6R6
• Locus tag: GK020_RS07775
• Protein ID: WP_016658124.1
• Coordinates: 1610804..1610968 (+)
• Length: 55 a.a.

Antitoxin (Protein)

• Gene name: NpoA
• Uniprot ID: -
• Locus tag: GK020_RS07770
• Protein ID: WP_045794748.1
• Coordinates: 1609853..1610722 (+)
• Length: 290 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GK020_RS07750	1605492..1605941	+	450	WP_045796755.1	cyanase	-
GK020_RS07755	1606130..1607125	-	996	WP_171501538.1	stress-induced protein	-
GK020_RS07760	1607611..1608852	-	1242	WP_156188959.1	MFS transporter	-
GK020_RS07765	1609511..1609750	+	240	WP_045794747.1	DUF2171 domain-containing protein	-
GK020_RS07770	1609853..1610722	+	870	WP_045794748.1	SDR family oxidoreductase	Antitoxin
GK020_RS07775	1610804..1610968	+	165	WP_016658124.1	hypothetical protein	Toxin
GK020_RS07780	1611069..1612472	-	1404	WP_156188960.1	iron-containing redox enzyme family protein	-
GK020_RS07785	1612829..1613950	-	1122	WP_156188961.1	acyl-CoA desaturase	-
GK020_RS07790	1613968..1614990	-	1023	WP_156188962.1	iron-sulfur cluster-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 55 a.a.
• Molecular weight: 6182.76 Da
• Isoelectric Point: 10.1466

>T144148 WP_016658124.1 NZ_CP046392:1610804-1610968 [Acinetobacter indicus]
MSRGDKSAYTDKQKRQARHIIESEKERGHSEEEAERIGWSTVNKQDGGGKKKSH

Nucleotide

• Length: 165 bp

>T144148 NZ_CP061754:1935880-1936131 [Escherichia coli O18ac:H14]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 290 a.a.
• Molecular weight: 31852.95 Da
• Isoelectric Point: 4.7467

>AT144148 WP_045794748.1 NZ_CP046392:1609853-1610722 [Acinetobacter indicus]
MNHYPDSPSPQEKQEHQPGVQYKMTPEPEIIKSNYQGSQKLKDKVALITGGDSGIGRSVAVLFAREGANIIIPYLEEDQD
AQDTKRLVEQEGCQCLLIQCDLRQHAAVQQMVDLALQQFPHINILVNNAAVQYPQKTIEDINPEQLHKTFETNLYPLFYV
TQLLIPQMQPGDSIINTTSITSYQGHNELIDYASTKGAITAFTRSLSTNLLKNKTGIRVNGVAPGPIWTPLIPSSFDEEQ
LKGFGEDTPMGRMGQPSEVAPAYLFLASDEASYISGQVIHVNGGTIVNG

Nucleotide

• Length: 870 bp

>AT144148 NZ_CP061754:1936128-1936382 [Escherichia coli O18ac:H14]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: V2U6R6