Detailed information of TA system TA144147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 828108..828730
• Replicon: chromosome
• Accession: NZ_CP046392
• Organism: Acinetobacter indicus strain WMB-7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: GK020_RS03960
• Protein ID: WP_104989019.1
• Coordinates: 828108..828503 (-)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: N8WVG5
• Locus tag: GK020_RS03965
• Protein ID: WP_004779823.1
• Coordinates: 828500..828730 (-)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GK020_RS03940	823495..824418	-	924	WP_104989021.1	tRNA-dihydrouridine synthase	-
GK020_RS03945	824596..825921	-	1326	WP_001280601.1	ISNCY family transposase	-
GK020_RS03950	826149..826547	+	399	WP_104989020.1	hypothetical protein	-
GK020_RS03955	826799..828007	+	1209	WP_104987963.1	IS256 family transposase	-
GK020_RS03960	828108..828503	-	396	WP_104989019.1	type II toxin-antitoxin system VapC family toxin	Toxin
GK020_RS03965	828500..828730	-	231	WP_004779823.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
GK020_RS03970	829297..829653	-	357	WP_156188831.1	hypothetical protein	-
GK020_RS03975	829695..830627	+	933	WP_004811110.1	IS5 family transposase	-
GK020_RS03980	830679..831212	+	534	Protein_755	TerC family protein	-
GK020_RS03985	831471..832280	-	810	WP_016659852.1	cytochrome c biogenesis protein CcsA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	IScluster/Tn	-	-	824596..830627	6031

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-124)

Antitoxin

• SpoVT-AbrB domain (7-37)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 14893.12 Da
• Isoelectric Point: 6.2253

>T144147 WP_104989019.1 NZ_CP046392:c828503-828108 [Acinetobacter indicus]
MIYLLDTNICIYVINNKPQHVFERFRQYQLGQLAISSITASELAFGVEKSGSERNKQALNKFLSPLEILPYDEQAIWHYA
KLRQDLQSTGKPIGSLDMLIAAHALALDVVLVTNNTKEFERIDGLKLENWG

Nucleotide

• Length: 396 bp

>T144147 NZ_CP061754:c1215400-1215023 [Escherichia coli O18ac:H14]
ATGCAAACCCAACCACTATCCTCAACGCAGGAGGCTACATCACGCCCGTCACCGGTGGAGATCTGGCAACGGCTTCTGAG
CCACCTGTTGGATCGTCACTACGGTCTGACACTCAACGACACTCCGTTCGGCAACGATGGCGTGATTCAGGAGCATATCG
ATGCCGGTATCTCACTGTGCGACGCGGTGAATTTTATCGTGGAGAAATACGATCTGGTACGAACCGACCGTCGCGGTTTT
AACGCAGAAACACAGTCGCCTCTTCTCAGCAGTATCGATATTCTCCGCGCCCGCAAAGCCACCGGACTGATGACCCGAAA
CGATTACAGAACGGTGACCGACATCACCACCGGTAAATACCGGGAGGTGCAGCCATGA

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8750.97 Da
• Isoelectric Point: 4.7708

>AT144147 WP_004779823.1 NZ_CP046392:c828730-828500 [Acinetobacter indicus]
MEIAKVFQTGRSQAVRLPKAFRFNGTEVAIKSFGRGVLLMPIDNPWDVMLEAINEFEGGFQLERADQGEQFREEFR

Nucleotide

• Length: 231 bp

>AT144147 NZ_CP061754:c1215810-1215451 [Escherichia coli O18ac:H14]
TTGTCGAATAAAATACCGACAGTAAACCACGATATCACTGAACCCTGGTGGGGGCTTAAACGCAGTATCACGCCCTGTTT
TGGCGCACGGCTGGTGCAGGCGGGCAACTGTCTGCATTATCTCGCTGACCGGGCCAGCATCACCGGACAGTTCAGCGACG
GGGATTTACGGCATCTCGACCAGGCATTTCCACTGCTGCTCAAACAGCTTGAACTGATGCTCACCAGCGGTGAACTCACT
CCCCGCCATCAGCACTGTGTCACGCTCTATGCAAAAGGGCTGACCTGCGAGGCCGACTCCCTCGGCTCGCATGGTTACGT
ATACCTGGCGATTTATCCGACACCAGCGGCAACCGCGTAA

Structures

Antitoxin

• AlphaFold DB: N8WVG5