Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1681724..1682392 Replicon chromosome
Accession NZ_CP046379
Organism Streptococcus pneumoniae strain 563

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag GL187_RS08475 Protein ID WP_001132284.1
Coordinates 1682213..1682392 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag GL187_RS08470 Protein ID WP_000961810.1
Coordinates 1681724..1682176 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL187_RS08440 1677144..1677887 - 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
GL187_RS08445 1677889..1678839 - 951 WP_024477875.1 50S ribosomal protein L11 methyltransferase -
GL187_RS08450 1678977..1679450 - 474 WP_000631889.1 GNAT family N-acetyltransferase -
GL187_RS08455 1679447..1679875 - 429 WP_024477876.1 NUDIX hydrolase -
GL187_RS08460 1679856..1680944 - 1089 WP_024477877.1 M50 family metallopeptidase -
GL187_RS08465 1680963..1681433 - 471 WP_000257084.1 DUF3013 family protein -
GL187_RS08470 1681724..1682176 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GL187_RS08475 1682213..1682392 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
GL187_RS08480 1682529..1682777 - 249 WP_000797240.1 hypothetical protein -
GL187_RS08485 1682767..1682982 - 216 WP_075329187.1 hypothetical protein -
GL187_RS08490 1683280..1684551 + 1272 WP_001113213.1 replication-associated recombination protein A -
GL187_RS08500 1685099..1686418 - 1320 WP_024477878.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T144128 WP_001132284.1 NZ_CP046379:c1682392-1682213 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T144128 NZ_CP061749:2866041-2866148 [Escherichia coli O15:H12]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT144128 WP_000961810.1 NZ_CP046379:c1682176-1681724 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT144128 NZ_CP061749:c2865991-2865928 [Escherichia coli O15:H12]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References