Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1193271..1193769 Replicon chromosome
Accession NZ_CP046379
Organism Streptococcus pneumoniae strain 563

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag GL187_RS05975 Protein ID WP_001809704.1
Coordinates 1193271..1193525 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0U0E6Y1
Locus tag GL187_RS05980 Protein ID WP_024477795.1
Coordinates 1193527..1193769 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL187_RS05970 1191325..1193196 - 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
GL187_RS05975 1193271..1193525 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GL187_RS05980 1193527..1193769 - 243 WP_024477795.1 hypothetical protein Antitoxin
GL187_RS05985 1193860..1194669 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
GL187_RS05990 1194671..1196020 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
GL187_RS05995 1196013..1196717 - 705 WP_000722076.1 response regulator transcription factor -
GL187_RS06000 1196772..1197947 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T144127 WP_001809704.1 NZ_CP046379:c1193525-1193271 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T144127 NZ_CP061749:2865506-2865613 [Escherichia coli O15:H12]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9187.42 Da        Isoelectric Point: 4.0527

>AT144127 WP_024477795.1 NZ_CP046379:c1193769-1193527 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMIHDLGLKDE

Download         Length: 243 bp

>AT144127 NZ_CP061749:c2865459-2865393 [Escherichia coli O15:H12]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A0U0E6Y1

References