Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 997184..998427 Replicon chromosome
Accession NZ_CP046379
Organism Streptococcus pneumoniae strain 563

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag GL187_RS05105 Protein ID WP_050210402.1
Coordinates 997660..998427 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag GL187_RS05100 Protein ID WP_000579599.1
Coordinates 997184..997660 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL187_RS05070 993087..994040 - 954 WP_001155339.1 IS30-like element ISSpn8 family transposase -
GL187_RS05075 994412..995050 + 639 WP_024477682.1 hypothetical protein -
GL187_RS05080 995060..996145 + 1086 WP_024477681.1 toprim domain-containing protein -
GL187_RS05085 996196..996429 + 234 WP_024477680.1 hypothetical protein -
GL187_RS05090 996426..996809 + 384 WP_002933294.1 hypothetical protein -
GL187_RS05095 996847..997110 + 264 Protein_1003 hypothetical protein -
GL187_RS05100 997184..997660 + 477 WP_000579599.1 helix-turn-helix domain-containing protein Antitoxin
GL187_RS05105 997660..998427 + 768 WP_050210402.1 zeta toxin family protein Toxin
GL187_RS05110 998462..1000081 + 1620 WP_078133416.1 DUF4297 domain-containing protein -
GL187_RS05115 1000068..1000607 + 540 WP_024477676.1 hypothetical protein -
GL187_RS05120 1000597..1003236 + 2640 WP_078133417.1 SMC family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) / erm(B) - 925847..1032860 107013
- flank IS/Tn - - 993087..994040 953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29310.43 Da        Isoelectric Point: 7.4385

>T144126 WP_050210402.1 NZ_CP046379:997660-998427 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEKLAIFERIQIYQRDRSCVYDSKENTTSAAEVLQECLFGKWSKVEEEML
KVGEEILETLCNRTE

Download         Length: 768 bp

>T144126 NZ_CP061749:c2657905-2657729 [Escherichia coli O15:H12]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18251.60 Da        Isoelectric Point: 4.3571

>AT144126 WP_000579599.1 NZ_CP046379:997184-997660 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFSRIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT144126 NZ_CP061749:c2657683-2657267 [Escherichia coli O15:H12]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTGCCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References