Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2831233..2831858 Replicon chromosome
Accession NZ_CP046377
Organism Pectobacterium polaris strain PZ1

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag GMX10_RS12895 Protein ID WP_005976087.1
Coordinates 2831233..2831436 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A6P1S9D7
Locus tag GMX10_RS12900 Protein ID WP_039487867.1
Coordinates 2831490..2831858 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMX10_RS12870 2827103..2828431 + 1329 Protein_2497 IS4 family transposase -
GMX10_RS12875 2828488..2829352 - 865 Protein_2498 acyl-CoA thioesterase II -
GMX10_RS12880 2829564..2830145 + 582 WP_039485508.1 YbaY family lipoprotein -
GMX10_RS12885 2830165..2830485 - 321 WP_010282239.1 MGMT family protein -
GMX10_RS12895 2831233..2831436 - 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
GMX10_RS12900 2831490..2831858 - 369 WP_039487867.1 Hha toxicity modulator TomB Antitoxin
GMX10_RS12905 2832456..2832599 - 144 WP_072012464.1 type B 50S ribosomal protein L36 -
GMX10_RS12910 2832617..2832865 - 249 WP_015839361.1 type B 50S ribosomal protein L31 -
GMX10_RS12915 2833052..2836180 - 3129 WP_039487869.1 multidrug efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T144119 WP_005976087.1 NZ_CP046377:c2831436-2831233 [Pectobacterium polaris]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T144119 NZ_CP061749:1168814-1169125 [Escherichia coli O15:H12]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14013.72 Da        Isoelectric Point: 4.4776

>AT144119 WP_039487867.1 NZ_CP046377:c2831858-2831490 [Pectobacterium polaris]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRHWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT144119 NZ_CP061749:1169122-1169541 [Escherichia coli O15:H12]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S9D7

References