Detailed information of TA system TA144118

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2480710..2481235
• Replicon: chromosome
• Accession: NZ_CP046377
• Organism: Pectobacterium polaris strain PZ1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GMX10_RS11335
• Protein ID: WP_161546820.1
• Coordinates: 2480710..2480994 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: GMX10_RS11340
• Protein ID: WP_005973616.1
• Coordinates: 2480984..2481235 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GMX10_RS11315	2475855..2477414	+	1560	WP_039486187.1	MFS transporter	-
GMX10_RS11320	2477458..2478597	+	1140	WP_039486186.1	glycoside hydrolase family 88 protein	-
GMX10_RS11325	2478969..2479715	-	747	WP_039486185.1	SDR family oxidoreductase	-
GMX10_RS11330	2480269..2480445	-	177	WP_161546819.1	hypothetical protein	-
GMX10_RS11335	2480710..2480994	-	285	WP_161546820.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GMX10_RS11340	2480984..2481235	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
GMX10_RS11345	2481496..2483823	-	2328	WP_161546821.1	toprim domain-containing protein	-
GMX10_RS11350	2483834..2484175	-	342	WP_161546822.1	DUF5375 family protein	-
GMX10_RS11355	2484172..2484438	-	267	WP_161546823.1	hypothetical protein	-
GMX10_RS11360	2484435..2484629	-	195	WP_005973630.1	hypothetical protein	-
GMX10_RS11365	2484622..2484819	-	198	WP_039488123.1	host cell division inhibitor Icd-like protein	-
GMX10_RS11370	2484807..2485167	-	361	Protein_2205	ash family protein	-
GMX10_RS11375	2485176..2485400	-	225	WP_161546824.1	hypothetical protein	-
GMX10_RS11380	2485397..2485657	-	261	WP_161546825.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11003.93 Da
• Isoelectric Point: 10.0483

>T144118 WP_161546820.1 NZ_CP046377:c2480994-2480710 [Pectobacterium polaris]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQHPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYQAAKDRL

Nucleotide

• Length: 285 bp

>T144118 NZ_CP061749:1098843-1099178 [Escherichia coli O15:H12]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAAGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT144118 WP_005973616.1 NZ_CP046377:c2481235-2480984 [Pectobacterium polaris]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT144118 NZ_CP061749:1098595-1098843 [Escherichia coli O15:H12]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6