Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2040748..2041301 Replicon chromosome
Accession NZ_CP046377
Organism Pectobacterium polaris strain PZ1

Toxin (Protein)


Gene name relE Uniprot ID A0A6P1S0I2
Locus tag GMX10_RS09305 Protein ID WP_039484573.1
Coordinates 2041026..2041301 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A6P1S4N1
Locus tag GMX10_RS09300 Protein ID WP_039484576.1
Coordinates 2040748..2041026 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMX10_RS09280 2036130..2037254 - 1125 WP_039484581.1 polysaccharide lyase -
GMX10_RS09285 2038105..2038356 + 252 WP_039484579.1 hypothetical protein -
GMX10_RS09290 2038916..2039209 + 294 WP_072012385.1 2Fe-2S iron-sulfur cluster binding domain-containing protein -
GMX10_RS09295 2039222..2039896 + 675 WP_039512666.1 hypothetical protein -
GMX10_RS09300 2040748..2041026 + 279 WP_039484576.1 ribbon-helix-helix domain-containing protein Antitoxin
GMX10_RS09305 2041026..2041301 + 276 WP_039484573.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GMX10_RS09310 2041380..2041478 + 99 Protein_1807 IS6 family transposase -
GMX10_RS09315 2041514..2041792 - 279 Protein_1808 transposase -
GMX10_RS09320 2041685..2042020 + 336 Protein_1809 recombinase family protein -
GMX10_RS09325 2042466..2042546 - 81 Protein_1810 IS1 family transposase -
GMX10_RS09330 2043861..2044436 + 576 WP_014916837.1 aminodeoxychorismate synthase component II -
GMX10_RS09335 2044556..2045782 + 1227 WP_039484568.1 aspartate aminotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2041514..2041705 191


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(12-49)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10682.30 Da        Isoelectric Point: 7.3183

>T144116 WP_039484573.1 NZ_CP046377:2041026-2041301 [Pectobacterium polaris]
MEIKWTSKALSDLAHLYEFLALANKSAAARAVQELTQAPAILLTNSRLGEQLFQFEPREIRRFLVGEYEVRHEIEKSVIY
VLRIWHAREDR

Download         Length: 276 bp

>T144116 NZ_CP061749:c877798-877514 [Escherichia coli O15:H12]
ATGAAAACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGGTTGCTGGACCAGCATTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCTTGCGGATCGTTATTTACTACCGACTTGTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10278.70 Da        Isoelectric Point: 5.6845

>AT144116 WP_039484576.1 NZ_CP046377:2040748-2041026 [Pectobacterium polaris]
MKNDTQVVTRVLTAHVPLPIADKVDQIAARLERSRGWIMKQALSAWIAQEEERDRLTQEALADVDAGRVIDHQAVQAWAD
SLGTDKPLPVPR

Download         Length: 279 bp

>AT144116 NZ_CP061749:c878214-877888 [Escherichia coli O15:H12]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGACCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCGCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCTTCGGCTCCTGTGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAACGAA
AAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6P1S0I2

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1S4N1

References