Detailed information of TA system TA144109

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacT-ataR/DUF1778(antitoxin)
• Location: 852497..853239
• Replicon: chromosome
• Accession: NZ_CP046377
• Organism: Pectobacterium polaris strain PZ1

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: GMX10_RS03955
• Protein ID: WP_039481845.1
• Coordinates: 852497..852976 (-)
• Length: 160 a.a.

Antitoxin (Protein)

• Gene name: ataR
• Uniprot ID: A0A6P1S083
• Locus tag: GMX10_RS03960
• Protein ID: WP_039481848.1
• Coordinates: 852967..853239 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GMX10_RS03915	848286..848546	+	261	WP_161546673.1	AlpA family transcriptional regulator	-
GMX10_RS03920	848543..848767	+	225	WP_015841426.1	hypothetical protein	-
GMX10_RS03925	848776..849138	+	363	Protein_761	ash family protein	-
GMX10_RS03930	849123..849320	+	198	WP_146043581.1	host cell division inhibitor Icd-like protein	-
GMX10_RS03935	849313..849507	+	195	WP_005973630.1	hypothetical protein	-
GMX10_RS03940	849504..849770	+	267	WP_103160155.1	hypothetical protein	-
GMX10_RS03945	849767..850108	+	342	WP_103204047.1	DUF5375 family protein	-
GMX10_RS03950	850119..852443	+	2325	Protein_766	DNA primase	-
GMX10_RS03955	852497..852976	-	480	WP_039481845.1	GNAT family N-acetyltransferase	Toxin
GMX10_RS03960	852967..853239	-	273	WP_039481848.1	DUF1778 domain-containing protein	Antitoxin
GMX10_RS03965	853530..853781	+	252	WP_005973616.1	prevent-host-death protein	-
GMX10_RS03970	854656..855186	+	531	Protein_770	integrase arm-type DNA-binding domain-containing protein	-
GMX10_RS03975	855633..855917	-	285	WP_005971242.1	helix-turn-helix domain-containing protein	-
GMX10_RS03980	855907..856236	-	330	WP_039481852.1	type II toxin-antitoxin system RelE/ParE family toxin	-
GMX10_RS03985	856541..856957	+	417	Protein_773	GNAT family N-acetyltransferase	-
GMX10_RS03990	857048..858169	+	1122	WP_039481856.1	cupin domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	842931..856236	13305

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (30-147)

Antitoxin

• Vibrio phage ICP1, Orf50 (3-90)

Sequences

Toxin

Protein

• Length: 160 a.a.
• Molecular weight: 17429.04 Da
• Isoelectric Point: 8.9715

>T144109 WP_039481845.1 NZ_CP046377:c852976-852497 [Pectobacterium polaris]
VGITAPELLLPQHAVVDFRSSEPSLDDWLKRKALKNQTIGASRTFVVCESGANQVIGFYALATGSVQRQSVSGALRRNMP
DPLPVLVLGRLAVDERYHRRGIGAGLLKDAVLRSQQVAEQVGTKALLVHALSEEAKDFYLHWGFTSSEIQPSTLLLPLW

Nucleotide

• Length: 480 bp

>T144109 NZ_CP061746:150818-152143 [Enterobacter hormaechei]
ATGAGCCGGAAACAGCAGCGTCTGGCAATCTGGATGAACGGAATCAAAGTCGGATACTGGGAAAAAAGTAAAGGGGTAGA
CAGCTTACAATACCTTCCTGACTGGAGTGCAGACGAACAGGGAAGGCCGCTGTCATTGTCCCTTCCTTTTACTCCCGGGA
ACCAGGTCTGGCGTGGAAATGTGGTACGTGACTATTTTGATAATTTACTCCCGGACAGCGAAGGCATACGCAGACGTCTG
GCAATGCGTTACAAGGCCGATAGCCTGGAGCCTTTTGATCTTCTGACGGAGCTGGGAAAAGACTGCGTGGGCGCGATACA
GCTGCTTCATGACGGAGATGAACCCACAGATTTATATTCCGTGAAGTATCACCCGCTTACTGAATCAGAAATTGCGGCAA
CTTTGCGTAATACCACGGAGACATTGCTACCGGGCAGGCCAGAAGATAACGACGACTTACGTTTATCTATTGCCGGTGCT
CAGGAGAAAACAGCCCTACTGTGGCATGAAGATCGGTGGTGTATGCCGGAGGGTAATACACCAACGACGCATATATTCAA
GCTACCGCTCGGACTTGTGGGGAACATGAAAGCCGACATGCGCTCGTCGGTTGAAAATGAATGGCTCTGCTCGGTACTTC
TCGAACAGTACGGGCTCCCCGTGGCAAGAACGCAGATTGCTCACTTTGAAGATCAGAAAGCGCTGGTGGTAGAACGTTTT
GACCGAAAATGGTCAGGAAACGGACAATGGATCATTCGTTTACCCCAGGAGGATATGTGTCAGGCCCTGGGCATTTCGCC
ATTACGAAAATATCAGGCGGACGGCGGGCCAGGTATATCGGAAATTATGGAAGTTCTGAGTAATTCAGACCGTGCTGAGC
GTGACAAAGCGCAGTTTTTTATGACGCAGATAGTTTTCTGGATGATGGCCGCAACAGATGGCCACGCTAAAAATTTCAGT
ATTTCTATTGGGCCACAGGGACGTTATCACCTTACACCACTCTATGATGTGTTGTCGGCATGGCCGGTGATCGGTCATGG
GAACAATCAGATATCCTGGCAGAAGTGCAAACTGGCGATGGCCGTACGTGGCAGTAGCAACTATTACCAGATATATCGAA
TACAACGACGCCACTGGATCAGGCATGGTGAGATAACCGGCCTGAGTAAACAGCAGACAGAGGCGATGATAGAGGAAATC
ATCGCCAGAACCCCGGGTGTCATTGAACGTGTTAGCGGGCTTCTTCCGGACCAGTTCCCCCAGCAGCTTGCGGAAAGTAT
TTTTGATGGAATGAGGCAGCAATGCAGGCGCCTGGCTGAGAAATGA

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10288.77 Da
• Isoelectric Point: 4.7174

>AT144109 WP_039481848.1 NZ_CP046377:c853239-852967 [Pectobacterium polaris]
MRTEAKEAPINIRAKSSQRELIDVAAKLLSKSRTDFILEAACREAEEVLLDQRLFLVDESQFDAFITALEKPVATNERLQ
ALLDRKSPWE

Nucleotide

• Length: 273 bp

>AT144109 NZ_CP061746:150520-150813 [Enterobacter hormaechei]
ATCAATAATGATTACCCGTTAAACACGCTCAACCAGTTGCGTCCCTTGCTCATTGGTTTTCGCAAGGCGAATGGCCTGAC
GCAAAAAGACCTGTCCGAAAGGTTAGGGGTCACTCAACAGACATACTCACGTCTGGAAGCCAACCCTGCCAGTGCGAGCA
TTGAACGGCTATTCAAGGTGTTTTCTATCCTGGGCGTAAAAATCAGCTTCTCCTCGACAACCGCCTCTTCAGAGGGGAAG
CAGACGGAAGAAATGCTTAAATCAAACTCACCTGCACGACAGGAGAAATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6P1S083