Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3166294..3166954 Replicon chromosome
Accession NZ_CP046376
Organism Pectobacterium parmentieri strain HC

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B3EZX7
Locus tag GMW39_RS14805 Protein ID WP_012822581.1
Coordinates 3166294..3166707 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3I0G9
Locus tag GMW39_RS14810 Protein ID WP_012822580.1
Coordinates 3166688..3166954 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GMW39_RS14775 3161334..3162152 - 819 WP_025919822.1 MetQ/NlpA family ABC transporter substrate-binding protein -
GMW39_RS14780 3162170..3162838 - 669 WP_012822586.1 ABC transporter permease -
GMW39_RS14785 3162831..3163847 - 1017 WP_012822585.1 methionine ABC transporter ATP-binding protein -
GMW39_RS14790 3164175..3164693 + 519 WP_033070904.1 flavodoxin FldB -
GMW39_RS14795 3164722..3165045 + 324 WP_121331554.1 hypothetical protein -
GMW39_RS14800 3165133..3166068 - 936 WP_012822582.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
GMW39_RS14805 3166294..3166707 - 414 WP_012822581.1 protein YgfX Toxin
GMW39_RS14810 3166688..3166954 - 267 WP_012822580.1 FAD assembly factor SdhE Antitoxin
GMW39_RS14815 3167182..3168183 + 1002 WP_161546033.1 tRNA-modifying protein YgfZ -
GMW39_RS14820 3168238..3168885 - 648 WP_012822578.1 hemolysin III family protein -
GMW39_RS14825 3169296..3169904 + 609 WP_012822577.1 HD domain-containing protein -
GMW39_RS14830 3169958..3170962 + 1005 WP_103807861.1 substrate-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.20 Da        Isoelectric Point: 10.7923

>T144104 WP_012822581.1 NZ_CP046376:c3166707-3166294 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T144104 NZ_CP061744:c1059753-1059535 [Enterobacter hormaechei]
ATGTCTGATAAACCATTAACAAAAGTCGATTATTTGATGCGCCTGCGACGCTGCCAGTCAATTGACACCCTCGAACGTGT
TATTGAAAAAAATAAATACGAGCTCTCTGATAATGAACTGGCGGTATTTTATTCAGCTGCCGACCATCGTCTGGCTGAAC
TAACCATGAATAAACTGTATGACAAGATCCCCTCTTCGGTATGGAAATTTGTTCGTTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.99 Da        Isoelectric Point: 5.1392

>AT144104 WP_012822580.1 NZ_CP046376:c3166954-3166688 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT144104 NZ_CP061744:c1060155-1059781 [Enterobacter hormaechei]
ATGGACGAGTACTCGCCAAAAAGGCATGATATCGCGCAGTTGAAATTTCTCTGCGAATCCTTGTACCATGACTGCCTTGC
CAATCTTGAAGAAAGTAACCATGGCTGGGTGAACGATCCAACGTCTGCTATCAATTTACAGCTTAACGAGCTGATCGAGC
ATATCGCCACCTTCGCACTTAATTATAAAATTAAGTACAATGAAGATAATAAGTTGATAGAGCAAATTGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTACGGCATTAACGCACAGGATTTGCAGAAATGGCGTAAATCAGGAAACCGCCT
ATTTCGCTGCTTCACTAATGTCAGCAGAGCTAATCCGGTTAGTCTTTCCTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3EZX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I0G9

References