Detailed information of TA system TA144100

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 490903..491530
• Replicon: chromosome
• Accession: NZ_CP046376
• Organism: Pectobacterium parmentieri strain HC

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: C6DB72
• Locus tag: GMW39_RS02270
• Protein ID: WP_005976087.1
• Coordinates: 490903..491106 (-)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: -
• Locus tag: GMW39_RS02275
• Protein ID: WP_121247122.1
• Coordinates: 491162..491530 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GMW39_RS02240	486395..486733	+	339	WP_002208627.1	P-II family nitrogen regulator	-
GMW39_RS02245	486773..488059	+	1287	WP_014700821.1	ammonium transporter AmtB	-
GMW39_RS02250	488177..489040	-	864	WP_121265854.1	acyl-CoA thioesterase II	-
GMW39_RS02255	489251..489835	+	585	WP_015730971.1	YbaY family lipoprotein	-
GMW39_RS02260	489855..490175	-	321	WP_005976085.1	MGMT family protein	-
GMW39_RS02270	490903..491106	-	204	WP_005976087.1	hemolysin expression modulator Hha	Toxin
GMW39_RS02275	491162..491530	-	369	WP_121247122.1	Hha toxicity modulator TomB	Antitoxin
GMW39_RS02280	492289..492432	-	144	WP_005976091.1	type B 50S ribosomal protein L36	-
GMW39_RS02285	492450..492698	-	249	WP_015730970.1	type B 50S ribosomal protein L31	-
GMW39_RS02290	492931..496059	-	3129	WP_015730969.1	multidrug efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8145.52 Da
• Isoelectric Point: 8.9008

>T144100 WP_005976087.1 NZ_CP046376:c491106-490903 [Pectobacterium parmentieri]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Nucleotide

• Length: 204 bp

>T144100 NZ_CP061725:c3577559-3577302 [Micromonospora craniellae]
GTGAGGCTGGTCTTCACCGCGACAGCCTGGAGCCAGTACCTCAGCCACACCGACCGCAAGCTGGTCAAGCGCATCAACGA
CCTGATCGCGGACGTGATGCGCAACGGGTACGAGGGCATCGGCAAGCCGGAGCCCCTGCGGGGCGAGCTGTCCGGCTTCT
GGTCCCGCCGGATCGACCGCGAACACCGGCTGGTGTACCGGATCACCAAGGAGGACGTAAAGATCGTCGCCTGCCGCTAC
CACTATGGCGACCGATAG

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14004.71 Da
• Isoelectric Point: 4.3689

>AT144100 WP_121247122.1 NZ_CP046376:c491530-491162 [Pectobacterium parmentieri]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELQRWQKSKAKLFGMFSGENVCTPAKT

Nucleotide

• Length: 369 bp

>AT144100 NZ_CP061725:c3577831-3577556 [Micromonospora craniellae]
ATGCGGACCGTGAACTTCACCCAGCTACGCCAGAACCTGGCGGCCGAACTCGACAGCGTCATCGACGACGCCGAGGAGGT
GGTGGTGACCCGGTCTGGCCACGAGCCGGTGGTGATCGTGTCGCTTGCCGAGTACGAGTCGATGAAGGAAACCGAGTACC
TCCTGCGCAGCCCCAGCAACGCCGCAGCCCTCCGTCGATCGATCGCGGAGCTTGAGCAGGGCGACACGGCCGAGCGGGAG
CTGACCGACCCGGACGCCCGGCGGGACGCCGCGTGA

Structures

Toxin

• AlphaFold DB: A0A1D7Z3F0