144094

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1632772..1633440 Replicon chromosome
Accession NZ_CP046360
Organism Streptococcus pneumoniae strain 574

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag GL189_RS08245 Protein ID WP_001132284.1
Coordinates 1633261..1633440 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag GL189_RS08240 Protein ID WP_000961810.1
Coordinates 1632772..1633224 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL189_RS08210 1628192..1628935 - 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
GL189_RS08215 1628937..1629887 - 951 WP_024477875.1 50S ribosomal protein L11 methyltransferase -
GL189_RS08220 1630025..1630498 - 474 WP_000631889.1 GNAT family N-acetyltransferase -
GL189_RS08225 1630495..1630923 - 429 WP_024477876.1 NUDIX hydrolase -
GL189_RS08230 1630904..1631992 - 1089 WP_024477877.1 M50 family metallopeptidase -
GL189_RS08235 1632011..1632481 - 471 WP_000257084.1 DUF3013 family protein -
GL189_RS08240 1632772..1633224 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GL189_RS08245 1633261..1633440 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
GL189_RS08250 1633577..1633825 - 249 WP_197097193.1 hypothetical protein -
GL189_RS08255 1633815..1634030 - 216 WP_075329187.1 hypothetical protein -
GL189_RS08260 1634328..1635599 + 1272 WP_001113213.1 replication-associated recombination protein A -
GL189_RS08270 1636147..1637466 - 1320 WP_024477878.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T144094 WP_001132284.1 NZ_CP046360:c1633440-1633261 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T144094 NZ_CP061721:72451-72744 [Pseudarthrobacter sp. BIM B-2242]
GTGACCGGCACAGAACCCGGTGATACGGGGGCGTGGAAGGTCGAAGTCACGAGTCCGGCACTGAAGGGTTTCCGCCGGCT
CCCCGAGAAGGCGGCAGCAGCGATAGTTGAATTCGTCACCGGCCCGCTGGCCGATAATCCCCGGCGGCTGAGCAAACCCC
TCACGAATGAACTGCTCGGCCTGCACACGGCACGGCGCGGCGACTATCGCGTGCTGTTCACTCTCGACGTTGAAGACCAC
ATCCTGTACGTCCACCGCATCGAACACCGATCCGACGTCTACAAGCCGCGTTAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT144094 WP_000961810.1 NZ_CP046360:c1633224-1632772 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT144094 NZ_CP061721:72179-72454 [Pseudarthrobacter sp. BIM B-2242]
ATGAGAACCGTACCGCTCAGCGAAGCCAAGGACAAACTCTCGGCCCTCGTGGAGGAAGCCGACAGGACCCACGAGATCAT
TCAGATCACGCGGCACGGGCACCCGTCAGCGGTGCTGATGTCCGCGGATGACCTGGAATCCTTGCAGGAAACGATCCACT
GGCTGTCCCGGCCGGGCATCCGCGAAGACCTGGACCAGGCGCAGCGCGACATCGCCGAAGGCAACACGACCAGCGGTGCT
GATCTGCGCCGCGAATTCGGACTGCCGCCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
AlphaFold DB G0IC64

References