Detailed information of TA system TA144092

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1662476..1663144
• Replicon: chromosome
• Accession: NZ_CP046359
• Organism: Streptococcus pneumoniae strain 573

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: A0A0B7M7X4
• Locus tag: GL188_RS08365
• Protein ID: WP_001132284.1
• Coordinates: 1662965..1663144 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: G0IC64
• Locus tag: GL188_RS08360
• Protein ID: WP_000961810.1
• Coordinates: 1662476..1662928 (-)
• Length: 151 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GL188_RS08330	1657896..1658639	-	744	WP_001188201.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
GL188_RS08335	1658641..1659591	-	951	WP_024477875.1	50S ribosomal protein L11 methyltransferase	-
GL188_RS08340	1659729..1660202	-	474	WP_000631889.1	GNAT family N-acetyltransferase	-
GL188_RS08345	1660199..1660627	-	429	WP_024477876.1	NUDIX hydrolase	-
GL188_RS08350	1660608..1661696	-	1089	WP_024477877.1	M50 family metallopeptidase	-
GL188_RS08355	1661715..1662185	-	471	WP_000257084.1	DUF3013 family protein	-
GL188_RS08360	1662476..1662928	-	453	WP_000961810.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
GL188_RS08365	1662965..1663144	-	180	WP_001132284.1	type II toxin-antitoxin system HicA family toxin	Toxin
GL188_RS08370	1663281..1663529	-	249	WP_000797240.1	hypothetical protein	-
GL188_RS08375	1663519..1663734	-	216	WP_075329187.1	hypothetical protein	-
GL188_RS08380	1664032..1665303	+	1272	WP_001113213.1	replication-associated recombination protein A	-
GL188_RS08390	1665851..1667170	-	1320	WP_024477878.1	glycoside hydrolase family 32 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (6-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (17-114)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6713.95 Da
• Isoelectric Point: 11.0174

>T144092 WP_001132284.1 NZ_CP046359:c1663144-1662965 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Nucleotide

• Length: 180 bp

>T144092 NZ_CP061718:2795086-2795568 [Roseococcus sp. NIBR12]
GTGAGTGTCACCGCCTGGCGCATCGCCAGCGACACGCGGGGCTGGGCGGCGGATGACCTTTCGGGCGCCGGGGCCGAGGC
CACGGGTGGCCGGTGGAACCCGCCGGGGCAGGCGGTGGTCTATGCGTCCATGAGCCGGGCGCTGGCCTGCCTGGAGACGG
TGGTGCACCTGAACGCGGGCGGGCTGCCGCTGAACCGCTATCTGGTGGAACTGACCATTCCCGACGCGCTGTGGAAGGCC
GCGCGGCGCGAGACGCCGGAAAGCCTGCCCGTGGGCTGGGATGCGGAGCCCGCCAGCGCCACCAGTGAGCGCCTGGGCGG
GGAATGGCTGGCCGGCGGGGCGAGCGCGCTGCTGCTGGTGCCCTCGGTGGTCGTGCCGGAGGAGTGGAACCTGCTGCTGA
ACCCGCGCCATGCCGGGGCGGCGGGGGTGCGCGCGCGGAAGGTGCGGAAGTGGCTGTATGACCCGCGTCTGCGAAGGGCT
TGA

Antitoxin

Protein

• Length: 151 a.a.
• Molecular weight: 16659.46 Da
• Isoelectric Point: 3.7220

>AT144092 WP_000961810.1 NZ_CP046359:c1662928-1662476 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Nucleotide

• Length: 453 bp

>AT144092 NZ_CP061718:2794655-2795089 [Roseococcus sp. NIBR12]
ATGTCCCACGCCAGCTACGCCGCGATCTATGACGCGCCCGTCACGGCGCGCATCGGCCGCATCCGCGCGGGCGTGCCGGC
GACCACGGCCAAGGAATGGCTCGACCTGCCGGAGCTGGGCCGCAACGCCACCCTCAAGGCGCTGGACCTCGCCATCGCCA
CCTTCAACCGCAAGGTGAAGGAGCGCGGCACCCTCTCCCCCGCCGAGAGCGAGCGCGTGCTGGGCCTGGCCCGGCTGGTG
GGCCAGGTGGAATCCATGGTGCTGGAAGCCGGCGCGCCCGAGGGCTTCGACGCCCGCGCCTGGCTGGCGCGCTGGCTGCA
GGAGCCGCTGCCCGCGCTCGGCCATGCCCGCCCGCTGGATTTCCTCAACACCATGGAGGGGCAGCGCCTGGTTTCCGACA
CCCTCGCGAAGGCCATCAGCGGCGCCTACGCGTGA

Structures

Toxin

• AlphaFold DB: A0A0B7M7X4

Antitoxin

• AlphaFold DB: G0IC64