Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 988112..989355 Replicon chromosome
Accession NZ_CP046359
Organism Streptococcus pneumoniae strain 573

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag GL188_RS05050 Protein ID WP_024477678.1
Coordinates 988588..989355 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag GL188_RS05045 Protein ID WP_000579597.1
Coordinates 988112..988588 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL188_RS05015 984009..984962 - 954 WP_001155339.1 IS30-like element ISSpn8 family transposase -
GL188_RS05020 985334..985972 + 639 WP_024477682.1 hypothetical protein -
GL188_RS05025 985982..987067 + 1086 WP_024477681.1 toprim domain-containing protein -
GL188_RS05030 987118..987351 + 234 WP_024477680.1 hypothetical protein -
GL188_RS05035 987348..987731 + 384 WP_002933294.1 hypothetical protein -
GL188_RS05040 987769..988041 + 273 WP_024477679.1 hypothetical protein -
GL188_RS05045 988112..988588 + 477 WP_000579597.1 helix-turn-helix domain-containing protein Antitoxin
GL188_RS05050 988588..989355 + 768 WP_024477678.1 zeta toxin family protein Toxin
GL188_RS05055 989390..991009 + 1620 WP_078133416.1 DUF4297 domain-containing protein -
GL188_RS05060 990996..991535 + 540 WP_024477676.1 hypothetical protein -
GL188_RS05065 991525..994164 + 2640 WP_078133417.1 SMC family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element tet(M) / erm(B) - 916770..1025196 108426
- flank IS/Tn - - 984009..984962 953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29310.39 Da        Isoelectric Point: 7.4386

>T144089 WP_024477678.1 NZ_CP046359:988588-989355 [Streptococcus pneumoniae]
MGIQDYTDSEFKQALERNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFARKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEKLAIFERIQIYQRDRSCVYDSKENTTSAAEVLQECLFGKWSKVEEEML
KVGEEILETLCNRTE

Download         Length: 768 bp

>T144089 NZ_CP061714:c1210589-1209297 [Luteimonas sp. MC1825]
GTGACCGACGCCACCGTCCGCCTCTGGGGCCGCGACATCGGCGCGGTGAGCTGGCTGGAAGACCGCGACCGCGCGGTGTT
CCAGTACATGCCGGACTTCGCCGACAGCGGCATCCGCGTCGCCCCGATCATGATGCCGCCAGGCCGCGAACCCTTCGAAT
TCCCCGGCCTCCCGCGCGAGGCGTTCAAGGGCCTGCCGGGCATGCTCGCCGACGCCCTGCCCGACCGCTTCGGCAACGCG
CTCATCGACGCGTGGCTCGCCGCGCAAGGCCGCGCGCCCGGCAGCTTCAACCCGGTCGAGCGCCTTTGCTACATCGGCAG
CCGCGGCATGGGCGCGCTGGAATTCCATCCCAGCCTGTCGGGCCTGCCGCGGCAGTCACGCGCCGTCGAGATCGATGCCC
TCACCCGGCTCGCCAACGACGTGCTCAACCAGCGCGGCCAGCTTGCCGGCGCGCTGATGGGCGATGACGACCGCGGCGAC
CTCGAGGACATCCTGCGCGTGGGCACCTCCGCCGGTGGCGCGCGCGCCAAGGCCGTGCTGGCCTGGAACGAACAGACCGG
CGAGTTCCGCTCCGGCCAGGTCAAGGCCGGCGAAGGCTTCAGCGCCTGGCTGATCAAGTTCGACGGCATCAGCGACAACC
GCGACAAGGAGCTCGCCGACCCGCAAGGTTTCGGCCTGGTGGAATACGCCTTCCACCTGCTGGCGGTCGCCGCCGGCATC
GACATGAGCGCCTGCCGCATCCACCGCGAAGGCGGCCGCGCGCATTTCATGACCCGCCGCTTCGACCGCACATCCAGCGG
CGGCAAGCTGCACATGCAGTCACTGGCCGCGCTGCGCCATTTCGATTTCAACGCCGCCGGCGCGCATTCCTACGAGCAGG
CCGTGGAAACCATCCGCCTGCTCGGCCTGCCTGCGCTGGACATCGAGCAGCAGTTCCGCCGCGCCGTGTTCAACGTGCTG
ATCCGCAACCAGGACGACCACGTCAAGAACATCGCCTTCCTGATGAACCGCAAGGGCGAGTGGCGCCTGTCGCCCGCGTT
CGATGTCAGCTACGCGTACAACCCGCAGGGCAGCTGGACGCACCAGCACCAGATGAGCCTCAACGGCAAGCGCGACCATT
TTGAGGCGGAGGACTTCGTGCGGTTCGGGGCGTTCTGCGGCATCAAGCCGACGAAGGCGCGCGAGCTGGTGGCGGAGATC
CGAACGCAGGTGGAAGGTTGGATGGGGTTTGCCGAGCGGGCGGGCGTGCCGGAGCGCAGGGCGGTGGAGATCGGGCGGGC
CATGCGGGCGTAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18235.60 Da        Isoelectric Point: 4.3571

>AT144089 WP_000579597.1 NZ_CP046359:988112-988588 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT144089 NZ_CP061714:c1210945-1210586 [Luteimonas sp. MC1825]
ATGGACTCTTACACAGACCGTCATGCTACGATTCAAGCCTCCCTCCTCGCCCTCGGCGAGCGTCTGGCCCAGCTGCGCCT
CGCCCGCAACCTGACTCAGGCCGCGCTGGCCCGCGAGGCCGGCACGTCCGCCAGCAGCATCAAGCGCCTGGAAGCCGGCG
CCAACGCCTCGCTCGACACCCTGCTGCGCGTGCTGCAGGTCCTGGGGCTGGATGGCCGCCTGCTCGACAGCCTGCCCGCC
CCCGGCGTGCGCCCCGTGGAGCGCGCCAGGCTCGGCGGCCGCGAGCGCCGCCGCGCCAGCACGCCTGCGGAAACACCCAA
GGCCACCGACTGGGCCTGGGGCGAGGACGACAGTCCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References