Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1665814..1666482 Replicon chromosome
Accession NZ_CP046358
Organism Streptococcus pneumoniae strain 566

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag GL186_RS08415 Protein ID WP_001132284.1
Coordinates 1666303..1666482 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag GL186_RS08410 Protein ID WP_000961810.1
Coordinates 1665814..1666266 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL186_RS08380 1661234..1661977 - 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
GL186_RS08385 1661979..1662929 - 951 WP_024477875.1 50S ribosomal protein L11 methyltransferase -
GL186_RS08390 1663067..1663540 - 474 WP_000631889.1 GNAT family N-acetyltransferase -
GL186_RS08395 1663537..1663965 - 429 WP_024477876.1 NUDIX hydrolase -
GL186_RS08400 1663946..1665034 - 1089 WP_024477877.1 M50 family metallopeptidase -
GL186_RS08405 1665053..1665523 - 471 WP_000257084.1 DUF3013 family protein -
GL186_RS08410 1665814..1666266 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GL186_RS08415 1666303..1666482 - 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
GL186_RS08420 1666619..1666867 - 249 WP_197097193.1 hypothetical protein -
GL186_RS08425 1666857..1667072 - 216 WP_075329187.1 hypothetical protein -
GL186_RS08430 1667370..1668641 + 1272 WP_001113213.1 replication-associated recombination protein A -
GL186_RS08440 1669189..1670508 - 1320 WP_024477878.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T144088 WP_001132284.1 NZ_CP046358:c1666482-1666303 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T144088 NZ_CP061714:c304870-304574 [Luteimonas sp. MC1825]
ATGGTCGAGATCCTCAAGAGTGACACCTTCGATGCATGGTTACGCGCCTTGCGCGACCGTCAAGCAAAGGCTCGCATAGA
GGTGCGTATCCGGCGGTTGTCGCTGGAGAACCCAGGGCAGCACCGAGCGCTCAAGGGTGGGATCTGCGAGCTAAAAATAG
ATCACGGCCCCGGGTATCGGGTTTACTACACATTTCGTAATCAAACACTTGTGCTACTGCTCTGCGGCGGCACCAAATCC
ACCCAAAGCCAAGACATCAAGCTGGCGCAGGGCATTGCCAAGCAATGGGAGGACTAG

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT144088 WP_000961810.1 NZ_CP046358:c1666266-1665814 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT144088 NZ_CP061714:c304571-304278 [Luteimonas sp. MC1825]
ATGACCAAAGCTAAAGAGAAGTTCAGCCGCTACGACACCGCAGATTATCTGGAAACGGAAGCGGACATTGCTGCTTATTT
GACCGCATGCGCGGAAGAAGATGATCCCGCGCTGCTGGTGGCTGCGCTCGGAGATGTGGCTCGAGCTCGCAACATGACCC
AGCTCGCCGAGAAAACCGGCATGACCCGAATGGGCTTGTACAAGGCTCTTTCCGGGCAAGGAAACCCAAGCTTCGCTACG
GTATCCAAGGTCGCGCATGCGCTTGGCCTAAAGATCACGGTGGCAGCGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References