Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1957835..1958503 Replicon chromosome
Accession NZ_CP046357
Organism Streptococcus pneumoniae strain 525

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag GL185_RS09995 Protein ID WP_001132284.1
Coordinates 1957835..1958014 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag GL185_RS10000 Protein ID WP_000961810.1
Coordinates 1958051..1958503 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL185_RS09970 1953809..1955128 + 1320 WP_024477878.1 glycoside hydrolase family 32 protein -
GL185_RS09980 1955676..1956947 - 1272 WP_001113213.1 replication-associated recombination protein A -
GL185_RS09985 1957245..1957460 + 216 WP_075329187.1 hypothetical protein -
GL185_RS09990 1957450..1957698 + 249 WP_000797240.1 hypothetical protein -
GL185_RS09995 1957835..1958014 + 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
GL185_RS10000 1958051..1958503 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GL185_RS10005 1958794..1959264 + 471 WP_000257084.1 DUF3013 family protein -
GL185_RS10010 1959283..1960371 + 1089 WP_024477877.1 M50 family metallopeptidase -
GL185_RS10015 1960352..1960780 + 429 WP_024477876.1 NUDIX hydrolase -
GL185_RS10020 1960777..1961250 + 474 WP_000631889.1 GNAT family N-acetyltransferase -
GL185_RS10025 1961388..1962338 + 951 WP_024477875.1 50S ribosomal protein L11 methyltransferase -
GL185_RS10030 1962340..1963083 + 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T144084 WP_001132284.1 NZ_CP046357:1957835-1958014 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T144084 NZ_CP061710:c4675-4355 [Acinetobacter baumannii]
ATGTTATTCATTGAAACTAGTATTTTCACCAAGCAAATTAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTTCAGCA
AGATCTCTTGGTACAGCCTGATAAGGGCGACTTAATCAAGAATGGCGGTGGCATTCGTAAAGTACGTTGTGCTCAAGGAA
ATAAAGGCAAAAGTGGCGGTATCCGGGTGATTTATTATTGGGTCACAGAGGATGATCAGATCTTTTTCCTGGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACAGACAAAGAGACCTCGATCCTGCGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT144084 WP_000961810.1 NZ_CP046357:1958051-1958503 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT144084 NZ_CP061710:c4362-4090 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCCATCAAACGTAATGAGATAAAGGCAAG
TCGAGTCACAGAGCTTGAATTGCCGGATATTAAAGAAGTACGTGAGAAAACTGGCTTAACCCAGGCTGAATTTGCTGCAC
GGTTGCATATCAGTGCAAGAACCCTGCAAAACTGGGAACAAGGCCGTCGTTATCCGACTGGTCCTGCAGCGACTTTAATT
CGCATTCTGGATGCCCATCCAACTCTGATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References