Detailed information of TA system TA144083

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 368835..370072
• Replicon: chromosome
• Accession: NZ_CP046357
• Organism: Streptococcus pneumoniae strain 525

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: GL185_RS01905
• Protein ID: WP_000405365.1
• Coordinates: 369311..370072 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: GL185_RS01900
• Protein ID: WP_000579599.1
• Coordinates: 368835..369311 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GL185_RS01880	363908..364762	+	855	WP_024477726.1	ADP-ribosylglycohydrolase family protein	-
GL185_RS01885	364874..365758	+	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
GL185_RS01890	365921..367660	+	1740	WP_000423466.1	glycoside hydrolase family 13 protein	-
GL185_RS01895	367935..368390	+	456	WP_000500465.1	hypothetical protein	-
GL185_RS01900	368835..369311	+	477	WP_000579599.1	helix-turn-helix domain-containing protein	Antitoxin
GL185_RS01905	369311..370072	+	762	WP_000405365.1	zeta toxin family protein	Toxin
GL185_RS01910	370100..371256	+	1157	Protein_377	hypothetical protein	-
GL185_RS01915	372075..372434	+	360	WP_000003745.1	hypothetical protein	-
GL185_RS01920	372444..372809	+	366	WP_000263051.1	MobC family plasmid mobilization relaxosome protein	-
GL185_RS01925	372796..374661	+	1866	WP_000261795.1	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	335103..381608	46505

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29060.05 Da
• Isoelectric Point: 6.8511

>T144083 WP_000405365.1 NZ_CP046357:369311-370072 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T144083 NZ_CP061708:c3791-3471 [Acinetobacter baumannii]
ATGCTATTCATTGAAACCAGTATTTTTACCAAGCAAATCAAAGAGCTTGTGAGTGATGAAGAGTATCGTCAGCTCCAGCA
AGATCTCTTGGTACAGCCCGATAAAGGCGACTTAATCAAGAATGGCGGTGGTATCCGTAAAGTACGTTGTGCTCAAGGTA
ATAAGGGTAAAAGTGGTGGTATCCGGGTGATCTATTATTGGGTCACAGAGGATGATCAGATCTTTTTCCTAGTGGCTTAT
CCAAAGTCTGTGAAAGATAATCTGACCGACAAAGAGACCTCGATCCTACGTCAATTAGTGAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18251.60 Da
• Isoelectric Point: 4.3571

>AT144083 WP_000579599.1 NZ_CP046357:368835-369311 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFSRIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT144083 NZ_CP061708:c3478-3206 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACCTGGTTGCTTCAATCAAAGAAGCTGGTGCTATCAAACGTAATGAGATAAAGGCCAG
TCGAGTTACAGCGCTTGAATTGCCGGATATTAAAGAAGTACGTGAGAAAACTGGCTTAACCCAGGCAGAGTTTGCTGCAC
GTTTGCATATCAGCGCGAGAACTCTACAAAACTGGGAACAAGGCCGTCGCTATCCGACTGGTCCTGCAGCAACTTTAATT
CGTATTCTTGATGCTCATCCAAGTCTAATTTAG