Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 304475..304973 Replicon chromosome
Accession NZ_CP046357
Organism Streptococcus pneumoniae strain 525

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag GL185_RS01580 Protein ID WP_001809704.1
Coordinates 304719..304973 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0U0E6Y1
Locus tag GL185_RS01575 Protein ID WP_024477795.1
Coordinates 304475..304717 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL185_RS01555 300297..301472 + 1176 WP_000886147.1 A/G-specific adenine glycosylase -
GL185_RS01560 301527..302231 + 705 WP_000722076.1 response regulator transcription factor -
GL185_RS01565 302224..303573 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
GL185_RS01570 303575..304384 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
GL185_RS01575 304475..304717 + 243 WP_024477795.1 hypothetical protein Antitoxin
GL185_RS01580 304719..304973 + 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GL185_RS01585 305048..306919 + 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T144081 WP_001809704.1 NZ_CP046357:304719-304973 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T144081 NZ_CP061707:5177-5533 [Acinetobacter baumannii]
ATGTGGACCGTCATCACGACAGATCTATTTAATGAATGGCTTGAACAGCAAGATGAATCAACACAAGAGAAAGTCCTAGC
AGCTTTGGTTGTTCTACAGCAGCAGGGACCAAGTTTAGGTCGCCCTTTAGTGGATACCGTGTATAACTCTAAATTTACCA
ATATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTAAGAGCCTTTTTCGCATTTGATCCATTACGGCAAGCCATT
GTGCTGTGCATTGCTGATAAAGGCGGGAAAAAGCGATTTTATAAAGAGATGCTGGATATTGCAGATGAGCAATACGAACT
TCATCTCTCAACCCTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9187.42 Da        Isoelectric Point: 4.0527

>AT144081 WP_024477795.1 NZ_CP046357:304475-304717 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMIHDLGLKDE

Download         Length: 243 bp

>AT144081 NZ_CP061707:5526-5828 [Acinetobacter baumannii]
ATGGCTAAAACCTTACAGGAATTATTGGCTAGTCGCTCTCCAGAGAGCCAAGCTCGTATTCAAAAAATGGCTGATGAACT
ACTTTTAGAAACTCAGCTTCACCTTATTCGAGAAGAATTAGAGATTTCCCAAAAAGAACTGGCTGAAACCCTTGGAATCA
AGCAACCATCACTTTCAGCAATCGAAAACCGTGGAAATGACCTTAAGATTTCAACAATGAAAAAGTATGTTGAAGCTATG
GGAGGAAAGCTCCGTATTGATGTAGAGCTTCCAACAGGAAAACATATAGGATTCAATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A0U0E6Y1

References