Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 1142117..1143360 Replicon chromosome
Accession NZ_CP046356
Organism Streptococcus pneumoniae strain 521

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag GL184_RS05865 Protein ID WP_050210402.1
Coordinates 1142117..1142884 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag GL184_RS05870 Protein ID WP_000579599.1
Coordinates 1142884..1143360 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL184_RS05850 1137308..1139947 - 2640 WP_078133417.1 SMC family ATPase -
GL184_RS05855 1139937..1140476 - 540 WP_024477676.1 hypothetical protein -
GL184_RS05860 1140463..1142082 - 1620 WP_078133416.1 DUF4297 domain-containing protein -
GL184_RS05865 1142117..1142884 - 768 WP_050210402.1 zeta toxin family protein Toxin
GL184_RS05870 1142884..1143360 - 477 WP_000579599.1 helix-turn-helix domain-containing protein Antitoxin
GL184_RS05875 1143434..1143697 - 264 Protein_1112 hypothetical protein -
GL184_RS05880 1143735..1144118 - 384 WP_002933294.1 hypothetical protein -
GL184_RS05885 1144115..1144348 - 234 WP_024477680.1 hypothetical protein -
GL184_RS05890 1144399..1145484 - 1086 WP_024477681.1 toprim domain-containing protein -
GL184_RS05895 1145494..1146132 - 639 WP_024477682.1 hypothetical protein -
GL184_RS05900 1146504..1147457 + 954 WP_001155339.1 IS30-like element ISSpn8 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(M) - 1085578..1213545 127967
- flank IS/Tn - - 1146504..1147457 953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29310.43 Da        Isoelectric Point: 7.4385

>T144080 WP_050210402.1 NZ_CP046356:c1142884-1142117 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEKLAIFERIQIYQRDRSCVYDSKENTTSAAEVLQECLFGKWSKVEEEML
KVGEEILETLCNRTE

Download         Length: 768 bp

>T144080 NZ_CP046356:c1142884-1142117 [Streptococcus pneumoniae]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGACAGTGTAGAATATACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGAGATACAATCTTTTGATCGAGGGAACTTTACGAACAGTTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTAGAAAAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGAAGTGCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGTTG
AAGGTGGGAGAAGAGATTTTAGAAACCTTGTGTAATCGTACAGAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18251.60 Da        Isoelectric Point: 4.3571

>AT144080 WP_000579599.1 NZ_CP046356:c1143360-1142884 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFSRIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT144080 NZ_CP046356:c1143360-1142884 [Streptococcus pneumoniae]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAAGACGACTTTTCCCGAATTGTAGGAATTTC
TCGAAATAGCTTGAGCCGGTATGAAAATGGAACTAGTTCAGTCTCTACGGAACTAATAGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References