Detailed information of TA system TA144079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1109149..1110386
• Replicon: chromosome
• Accession: NZ_CP046356
• Organism: Streptococcus pneumoniae strain 521

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: GL184_RS05700
• Protein ID: WP_000405365.1
• Coordinates: 1109149..1109910 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: GL184_RS05705
• Protein ID: WP_000579599.1
• Coordinates: 1109910..1110386 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GL184_RS05680	1104560..1106425	-	1866	WP_000261795.1	relaxase/mobilization nuclease domain-containing protein	-
GL184_RS05685	1106412..1106777	-	366	WP_000263051.1	MobC family plasmid mobilization relaxosome protein	-
GL184_RS05690	1106787..1107146	-	360	WP_000003745.1	hypothetical protein	-
GL184_RS05695	1107965..1109121	-	1157	Protein_1076	hypothetical protein	-
GL184_RS05700	1109149..1109910	-	762	WP_000405365.1	zeta toxin family protein	Toxin
GL184_RS05705	1109910..1110386	-	477	WP_000579599.1	helix-turn-helix domain-containing protein	Antitoxin
GL184_RS05710	1110831..1111286	-	456	WP_000500465.1	hypothetical protein	-
GL184_RS05715	1111561..1113300	-	1740	WP_000423466.1	glycoside hydrolase family 13 protein	-
GL184_RS05720	1113463..1114347	-	885	WP_000710115.1	diacylglycerol kinase family lipid kinase	-
GL184_RS05725	1114459..1115313	-	855	WP_024477726.1	ADP-ribosylglycohydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	erm(B) / tet(M)	-	1085578..1213545	127967

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29060.05 Da
• Isoelectric Point: 6.8511

>T144079 WP_000405365.1 NZ_CP046356:c1109910-1109149 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

>T144079 NZ_CP061706:c49660-49340 [Acinetobacter baumannii]
ATGTTATTTATTGAAACCAGCATCTTTACCAAGCAAATTAAAGACCTTGTATCTGATGAGGAATATCGTCAACTTCAGGA
AGATCTTTTGGTACAGCCTGATAGAGGTGATCTAATCAAGAATGGCGGTGGTATTCGCAAAGTACGTTGTGCTCAAGGTA
ACAAAGGAAAAAGTGGTGGCATTCGGGTGATTTATTATTGGGTCACCGAGGATGATCAGATATTTTTCTTAGTGGCTTAT
CCAAAATCAGTGAAAGATAATTTAACAGATAAGGAAACAGCCATTCTGCGCCAACTCGTGAAGGAGCAATTTCATGGATA
A

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18251.60 Da
• Isoelectric Point: 4.3571

>AT144079 WP_000579599.1 NZ_CP046356:c1110386-1109910 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFSRIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT144079 NZ_CP061706:c49347-49075 [Acinetobacter baumannii]
ATGGATAACAACTTATTTGATGACTTGGTTGCTTCAATCAAAGAAGCTGGAGCTATCAAACGTAAAGAAGTTAAAGCAAG
TCGAGTTACAGAACTCGAACTACCAGATATTAAAGAAGTACGTGAAAAAACAGGCTTGAGCCAAAATGAGTTTGCTGCAC
GTCTGCATATTAGTCCTCGTACCCTGCAAAATTGGGAACAGGGACGACGCTATCCAACTGGACCAGCAGCTACATTGATT
CGAATTTTAGATGCTCATCCAAGTCTTATTTAA