Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 1180962..1182205 Replicon chromosome
Accession NZ_CP046355
Organism Streptococcus pneumoniae strain 475

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag GL183_RS06130 Protein ID WP_050210402.1
Coordinates 1180962..1181729 (-) Length 256 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag GL183_RS06135 Protein ID WP_000579599.1
Coordinates 1181729..1182205 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GL183_RS06115 1176153..1178792 - 2640 WP_078133417.1 SMC family ATPase -
GL183_RS06120 1178782..1179321 - 540 WP_024477676.1 hypothetical protein -
GL183_RS06125 1179308..1180927 - 1620 WP_078133416.1 DUF4297 domain-containing protein -
GL183_RS06130 1180962..1181729 - 768 WP_050210402.1 zeta toxin family protein Toxin
GL183_RS06135 1181729..1182205 - 477 WP_000579599.1 helix-turn-helix domain-containing protein Antitoxin
GL183_RS06140 1182279..1182542 - 264 Protein_1165 hypothetical protein -
GL183_RS06145 1182580..1182963 - 384 WP_002933294.1 hypothetical protein -
GL183_RS06150 1182960..1183193 - 234 WP_024477680.1 hypothetical protein -
GL183_RS06155 1183244..1184329 - 1086 WP_024477681.1 toprim domain-containing protein -
GL183_RS06160 1184339..1184977 - 639 WP_024477682.1 hypothetical protein -
GL183_RS06165 1185349..1186302 + 954 WP_001155339.1 IS30-like element ISSpn8 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element erm(B) / tet(M) - 1124423..1252390 127967
- flank IS/Tn - - 1185349..1186302 953


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29310.43 Da        Isoelectric Point: 7.4385

>T144076 WP_050210402.1 NZ_CP046355:c1181729-1180962 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEKLAIFERIQIYQRDRSCVYDSKENTTSAAEVLQECLFGKWSKVEEEML
KVGEEILETLCNRTE

Download         Length: 768 bp

>T144076 NZ_CP061705:1288913-1289095 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAGTCAAAATGATTGAAGCAGACGGTTGGTACTTAGTTAGGGTTAAAGGAAGTCATCATCACTT
CAAACATCCAACTAAAGGGGGCTTAGTTACTATCCCTCACCCAAAAAAGGAATTACCAAGCGGAACTGTTAAAAGCATTT
TGAAGCAAGCGGGTCTAAATTGA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18251.60 Da        Isoelectric Point: 4.3571

>AT144076 WP_000579599.1 NZ_CP046355:c1182205-1181729 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQDDFSRIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT144076 NZ_CP061705:1289160-1289564 [Acinetobacter baumannii]
ATGTTGTATCCAATTGCTATAGAAAGAGGTAACGACACCGAGGCTTATGGTGTTACTGTTCCAGATATTCCAGGTTGTTT
TAGTGCTGGCGACACTTTAGATGAAGCTATCGAGAACGTAAAAGAGGCTATTTCTGGCCATCTAGAAATCCTTGCTGAAG
ATGGCGAGGAGATTCCATTAGCATCTGATGTAAGTAAGTTTATAGATGATGCTGACTATAAAGGAATGATCTGGGCAGTT
ACAGAAGTTGATGTTAGTCGTTACTTAGGTAAGCCAGAAAAAATCAATGTCACTTTACCAAGTCGTTTAATTCATATAAT
TGATGAAAATGTAGGTAAAGGAAAAAGATTTAAAACCCGATCTGCATTTTTGGCCGCTGGTGCTGAAAAGCTACTACATG
CTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References