Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 936748..937246 Replicon chromosome
Accession NZ_CP046354
Organism Streptococcus pneumoniae strain 310

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag GLO74_RS04975 Protein ID WP_001809704.1
Coordinates 936992..937246 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0U0E6Y1
Locus tag GLO74_RS04970 Protein ID WP_024477795.1
Coordinates 936748..936990 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLO74_RS04950 932570..933745 + 1176 WP_000886147.1 A/G-specific adenine glycosylase -
GLO74_RS04955 933800..934504 + 705 WP_000722076.1 response regulator transcription factor -
GLO74_RS04960 934497..935846 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
GLO74_RS04965 935848..936657 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
GLO74_RS04970 936748..936990 + 243 WP_024477795.1 hypothetical protein Antitoxin
GLO74_RS04975 936992..937246 + 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
GLO74_RS04980 937321..939207 + 1887 WP_000150984.1 Eco57I restriction-modification methylase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T144070 WP_001809704.1 NZ_CP046354:936992-937246 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T144070 NZ_CP061701:c316843-316559 [Klebsiella pneumoniae]
ATGACCTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTAGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTCCATGGACGCAAAGACCAGTACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTGACCAAACACAGAAATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9187.42 Da        Isoelectric Point: 4.0527

>AT144070 WP_024477795.1 NZ_CP046354:936748-936990 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMIHDLGLKDE

Download         Length: 243 bp

>AT144070 NZ_CP061701:c317081-316833 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGTACTTTCAATGCAGG
AGAAGGTGCCCCGGTAGCCATACTCAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGTTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCTGTAATCGAGGTCAGTCTAGAT
GACCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A0U0E6Y1

References