144069

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 452810..453478 Replicon chromosome
Accession NZ_CP046354
Organism Streptococcus pneumoniae strain 310

Toxin (Protein)


Gene name hicA Uniprot ID A0A0B7M7X4
Locus tag GLO74_RS02455 Protein ID WP_001132284.1
Coordinates 452810..452989 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag GLO74_RS02460 Protein ID WP_000961810.1
Coordinates 453026..453478 (+) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GLO74_RS02430 448784..450103 + 1320 WP_024477878.1 glycoside hydrolase family 32 protein -
GLO74_RS02440 450651..451922 - 1272 WP_001113213.1 replication-associated recombination protein A -
GLO74_RS02445 452220..452435 + 216 WP_075329187.1 hypothetical protein -
GLO74_RS02450 452425..452673 + 249 WP_197097193.1 hypothetical protein -
GLO74_RS02455 452810..452989 + 180 WP_001132284.1 type II toxin-antitoxin system HicA family toxin Toxin
GLO74_RS02460 453026..453478 + 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
GLO74_RS02465 453769..454239 + 471 WP_000257084.1 DUF3013 family protein -
GLO74_RS02470 454258..455346 + 1089 WP_024477877.1 M50 family metallopeptidase -
GLO74_RS02475 455327..455755 + 429 WP_024477876.1 NUDIX hydrolase -
GLO74_RS02480 455752..456225 + 474 WP_000631889.1 GNAT family N-acetyltransferase -
GLO74_RS02485 456363..457313 + 951 WP_024477875.1 50S ribosomal protein L11 methyltransferase -
GLO74_RS02490 457315..458058 + 744 WP_001188201.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T144069 WP_001132284.1 NZ_CP046354:452810-452989 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGELNKYTERGIRKQAGL

Download         Length: 180 bp

>T144069 NZ_CP061701:c195033-194551 [Klebsiella pneumoniae]
GTGGGACGTTTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTGGCTGAGTTCGTCAGCGGTGAGGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCCCTCGGAGCTGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGCAGCGTCAACCATACAGAAGCGACAGGCAATCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGCGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAACCATCACAAACTCAGCAGCGAACATTGTTTCTTAGACTCCCT
TAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT144069 WP_000961810.1 NZ_CP046354:453026-453478 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT144069 NZ_CP061701:c195308-195021 [Klebsiella pneumoniae]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAATGGCCTGTCAGGCTGCCGAGAATGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGCGGAGTTCATCGACATGCTTGATGCACCTGTCGTAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0B7M7X4

Antitoxin

Source ID Structure
AlphaFold DB G0IC64

References