Detailed information of TA system TA144058

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1906315..1907998
• Replicon: chromosome
• Accession: NZ_CP046348
• Organism: Citrobacter portucalensis strain FDAARGOS_738

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: FOC46_RS09570
• Protein ID: WP_003830162.1
• Coordinates: 1907081..1907998 (+)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: FOC46_RS09565
• Protein ID: WP_003830160.1
• Coordinates: 1906315..1907088 (+)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC46_RS09535	1901685..1902335	+	651	WP_003830149.1	TIGR03759 family integrating conjugative element protein	-
FOC46_RS09540	1902311..1902841	+	531	WP_003830151.1	transglycosylase SLT domain-containing protein	-
FOC46_RS09545	1902838..1903245	+	408	WP_003830152.1	integrating conjugative element protein	-
FOC46_RS09550	1903242..1905275	+	2034	WP_003830154.1	type IV conjugative transfer system coupling protein TraD	-
FOC46_RS09555	1905238..1905504	+	267	WP_003830156.1	hypothetical protein	-
FOC46_RS09560	1905504..1906184	+	681	WP_003830158.1	TIGR03747 family integrating conjugative element membrane protein	-
FOC46_RS09565	1906315..1907088	+	774	WP_003830160.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
FOC46_RS09570	1907081..1907998	+	918	WP_003830162.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
FOC46_RS09575	1908037..1908339	+	303	WP_082190885.1	DUF4400 domain-containing protein	-
FOC46_RS09580	1908419..1910149	+	1731	WP_003830164.1	hypothetical protein	-
FOC46_RS09585	1910237..1910554	+	318	WP_003830165.1	RAQPRD family integrative conjugative element protein	-
FOC46_RS09590	1910551..1910784	+	234	WP_000187176.1	TIGR03758 family integrating conjugative element protein	-
FOC46_RS09595	1910803..1911129	+	327	WP_003830169.1	TIGR03745 family integrating conjugative element membrane protein	-
FOC46_RS09600	1911133..1911486	+	354	WP_000104330.1	TIGR03750 family conjugal transfer protein	-
FOC46_RS09605	1911483..1912109	+	627	WP_001272135.1	TIGR03746 family integrating conjugative element protein	-
FOC46_RS09610	1912106..1912894	+	789	Protein_1758	TIGR03749 family integrating conjugative element protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1885753..1963301	77548

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34791.78 Da
• Isoelectric Point: 4.7101

>T144058 WP_003830162.1 NZ_CP046348:1907081-1907998 [Citrobacter portucalensis]
MNKTSPYYRQVALLVRALPYVANEPCFALKGGTAINLFIRDFPRLSVDIDLAYIPLESREVALPNVREALTRIAAELETQ
AGLSAVLQTNNPDEMRIIVTTDDAQIKIEVSPVARGTLYPPQERDVVEAVEEEFGFAAIPVVSLPDLYGGKLCAALDRQH
PRDFYDVKMLLDTQGIDRAIFNGFIAYLLSHNRPLSEVLSPRWKDITEPFQNEFSGMTFEEVSLEELREVPERMLSALKA
HFTQQDFDFLRSFKRGEPDWNLAPEPHIQNLPAVQWKLRNIGRMSEEKRAQSLEKLEKVMTEWLS

Nucleotide

• Length: 918 bp

>T144058 NZ_CP061700:731424-731909 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGCCCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 29360.78 Da
• Isoelectric Point: 9.7487

>AT144058 WP_003830160.1 NZ_CP046348:1906315-1907088 [Citrobacter portucalensis]
MASKINWLLQNTSPGSLVLQSWLTRNNISPSLAFKYAQNGWLIKLRAGVYARAGREPDWSDALWCLQNQLEAPVHLAGLS
SLSWQGRSHYLQLKQSQCWLSVENKTILPKWFKEFPGVEWLMVSALKLPELDEKYQTELEVKGKRITASTPELAAYELLS
AVPQEISFEHAAELFQGLVNLNPRKVEKLLTLSQSVQTKRLYLFFASFYEHAWLKRVDTSKIDLGSGNRQIVVNGKLNKQ
YQITVPENFTKKGISHE

Nucleotide

• Length: 774 bp

>AT144058 NZ_CP061700:731134-731427 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA