Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/Tad-HTH_37
Location 2939890..2940590 Replicon chromosome
Accession NZ_CP046346
Organism Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)


Gene name tad Uniprot ID A0A2S9M997
Locus tag FOC30_RS27920 Protein ID WP_035951940.1
Coordinates 2940213..2940590 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID B9BQB8
Locus tag FOC30_RS27915 Protein ID WP_006405635.1
Coordinates 2939890..2940213 (-) Length 108 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC30_RS27895 2935239..2936699 + 1461 WP_006398686.1 PLP-dependent aminotransferase family protein -
FOC30_RS27900 2936858..2938756 + 1899 WP_105780125.1 molecular chaperone HtpG -
FOC30_RS27905 2938765..2939379 + 615 WP_155822838.1 chorismate lyase -
FOC30_RS27910 2939376..2939867 + 492 WP_155822839.1 DNA-deoxyinosine glycosylase -
FOC30_RS27915 2939890..2940213 - 324 WP_006405635.1 helix-turn-helix domain-containing protein Antitoxin
FOC30_RS27920 2940213..2940590 - 378 WP_035951940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC30_RS27925 2941132..2941386 - 255 WP_155822840.1 hypothetical protein -
FOC30_RS27930 2941614..2942531 + 918 WP_059787259.1 hypothetical protein -
FOC30_RS27935 2942728..2942961 + 234 WP_006398697.1 DUF3311 domain-containing protein -
FOC30_RS27940 2942958..2944508 + 1551 WP_006398698.1 sodium:solute symporter family protein -
FOC30_RS27945 2944613..2945062 - 450 WP_155822841.1 VOC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(23-114)

Antitoxin

Cro/C1-type helix-turn-helix domain

(30-85)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13604.61 Da        Isoelectric Point: 9.5844

>T144053 WP_035951940.1 NZ_CP046346:c2940590-2940213 [Burkholderia multivorans]
MGINSSMVPYTKPLYWLGSARRDLKAMPEAVQDTFGYALYLAQTGGKHDQAKPLRGFGSAGVLEVVESEDSGTYRAVYTV
KLGGAVYVLHCFQKKSCRGIATPKPDIELVRARLRAAEAHANGEK

Download         Length: 378 bp

>T144053 NZ_CP061699:c3281292-3280714 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTTCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAGGGCGAACAGGAACGCGCCGACCTGTTGCAGTTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGATAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGCTCGGCGCGACGCCTAG

Antitoxin


Download         Length: 108 a.a.        Molecular weight: 11828.69 Da        Isoelectric Point: 8.0686

>AT144053 WP_006405635.1 NZ_CP046346:c2940213-2939890 [Burkholderia multivorans]
MIEIERGSGNVYADLGTPDAEEMRVKAQLAAKIAEIIKTRKWTQQHAARLLGMTQPKLSNMLRGQFRGVSEAKMLDCLAK
LGRDVQIVVGPDRHSETEGHIEVVFAA

Download         Length: 324 bp

>AT144053 NZ_CP061699:c3281935-3281381 [Pseudomonas aeruginosa]
ATGACCAAGCCTCTCCCCTCTTCGTCCCTGGGCCCCGCCCTGCGTCGCTGGCGCCTGCTGCACCGGGTCAAGCAAACGCA
TGCCGCCGAATTGCTCGGCGTGGCGCAATCGACCATCTCGCGCTGGGAGTCCGGTACCCAGGCGCTGCTGGTGGAGGAAC
GGGCACGCCTGGAGCGTCTGCTCGGCGCCCGCCTGGAAGCCGCCGCCGACCAGGCACTGGCCCGCCTGGTCGAGGCCAAC
CCGCAACCCGTGCACCTGATCTGCGACCTCACCCATCGCCTGCTGGCCTGTTCGCCGGCACGCGCCGCGCAATTCGGCGT
GCCTCTCGGCGAACTGCTCGACCGTTCGCTGTGGCCCTATTGCAGCGAGGAAATCCTCCGCCAGGAAGCCACCCTCGAGG
AACTCGGCTGGCGCGAACTGCTGGCAGCGCCGGCGCTGGAGTTCGCCAGCGGAGCGAACGCCTCGGCCATCGTGCCGATC
CGGCGCAGCCGTTGCCGCTGGACCCGCATGACCCTATCGGATGGACGCGCGGTACGCCTGGTGGAAACCCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S9M997

Antitoxin

Source ID Structure
AlphaFold DB B9BQB8

References