144052

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-vagC/VapC-VagC
Location 1944245..1944882 Replicon chromosome
Accession NZ_CP046346
Organism Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)


Gene name vapC Uniprot ID A0A0H3KIE2
Locus tag FOC30_RS23275 Protein ID WP_012212496.1
Coordinates 1944245..1944646 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID J5BG47
Locus tag FOC30_RS23280 Protein ID WP_006415629.1
Coordinates 1944646..1944882 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC30_RS23265 1941566..1942708 + 1143 WP_006401424.1 alginate lyase family protein -
FOC30_RS23270 1942735..1944123 + 1389 WP_006401425.1 L-serine ammonia-lyase -
FOC30_RS23275 1944245..1944646 - 402 WP_012212496.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC30_RS23280 1944646..1944882 - 237 WP_006415629.1 hypothetical protein Antitoxin
FOC30_RS23285 1945071..1946774 + 1704 WP_105765206.1 thiamine pyrophosphate-binding protein -
FOC30_RS23290 1946771..1947868 + 1098 WP_155822583.1 ADP-heptose--LPS heptosyltransferase -
FOC30_RS23295 1947996..1949027 - 1032 WP_012212492.1 helix-turn-helix domain-containing protein -
FOC30_RS23300 1949191..1949733 - 543 WP_155822584.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-116)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14930.10 Da        Isoelectric Point: 6.2246

>T144052 WP_012212496.1 NZ_CP046346:c1944646-1944245 [Burkholderia multivorans]
MPRYMLDTNMCIYLMKNQPEQVARRFAQCYTGDVVMSAITYAELEYGVTVCANPARERRNLAALIEDIPVAPFDGAAAQA
YGPIREATRERKKDHLDKLIGAHAVSLDVVLVTNHERDFAGYPGLRLENWLTG

Download         Length: 402 bp

>T144052 NZ_CP061699:2332788-2333543 [Pseudomonas aeruginosa]
GTGAGCGAGATCTGGCGACAGTGCAAGGGTGAGCGGCATGTCCGACCGCTCCAGGGGCGGCTGGTGCGGTTGGTGGAGAG
CCAGGAGCAGGTGGCGACCCTGCAATTGGTCGACACCCTGGAAGAACAGGCGTTGCTCGAGGAACTGCTCGAGTCGAGCA
AGCCGCCGGTGCCGGCGGATGCCGAGCCATTGCATTACCTGTTGAAGACCCCGTTCCGTTATCCGCCCTTGCGCTGGGGG
TCGCGGTTTGGCCGTCGCCACGAGCCAAGCCTGTTCTACGCCGCGTTGAAGCTGGAAACGGCCATGGCCGAAAGCGCGTA
TTACCGTTGCGTCCTGTGGAGTGGCATGGCGGTGCCGCCACCGAGCGGGAGGATTCTGTCCGAGCACGCTTCGTTCGAGG
CGGGCTGGAAGGTGGAGCGGGGAATCCGTCTGCAGGCGCCGCCTTTCTCCGATCACGAGGCTGCGCTGACCGACATCGCC
GACTACCGCGCTCCCCAGGAACTGGGGAGTGCCATGCGCAGCGCCGGGGTGCAGGCATTCGAATACCGTTCGGCGCGTTG
CCCGGAGCGCGGCTGCAATGTCGCCCTGTTCACGCCCGCGGCCTTCACCGAAAAGCGTCCTCGCAACCTGACGCCCTGGC
TGTGCGAAACCACGGCCGGTTACGTGGCCTTCAAGCCGGCGCATGTGCCGGGGTCGCCGAAAATCTTCTCCTGGGAGCTG
TTCCTGGTGGACGGAAAGTTGCCGCATCCGGCGTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8973.04 Da        Isoelectric Point: 5.1651

>AT144052 WP_006415629.1 NZ_CP046346:c1944882-1944646 [Burkholderia multivorans]
MHTTRVFRNGNSQAVRIPADLAYERSDIELEIERVGDEIRIRPARRPLTGVLGKFAKFGPDFMAEGRGDQEQAEREDW

Download         Length: 237 bp

>AT144052 NZ_CP061699:2332285-2332653 [Pseudomonas aeruginosa]
ATGAGCGCTCTCATCAAGGAACGTCCCAGCGCCGATGCCGTCCTGGCCAAGGCCGTCCTGGCCGCGCGCGAGCAATTGGG
GCTGACGCAGCTCGAACTGGCCGGCATCGTCGGCGTCGATCGCAGCGCCATCAGCCGCTGGAAGACCCAGGGCCTGCGGG
TGGACAGCAAGACCGGCGAGCTGGCTCTGCTGCTGGTGCGGGTCTATCGCGCACTGTATGCCCTGTTCGGCGGGCAGCAG
GAGGACATGCGCCACTTCCTGCGCACTCCCAACCATCACCTGGCGGGCGAGCCGCTGGCACTGATGGGACAGGTGCAGGG
CCTGGTTCATGTGCTGGAATACCTCGATGCGATCCGCGGCAAGGTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KIE2

Antitoxin

Source ID Structure
AlphaFold DB J5BG47

References