Detailed information of TA system TA144051

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1559956..1560512
• Replicon: chromosome
• Accession: NZ_CP046346
• Organism: Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: FOC30_RS21430
• Protein ID: WP_024429387.1
• Coordinates: 1559956..1560246 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: M4UBZ0
• Locus tag: FOC30_RS21435
• Protein ID: WP_004541313.1
• Coordinates: 1560234..1560512 (-)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC30_RS21405	1555438..1555959	+	522	WP_060401817.1	hypothetical protein	-
FOC30_RS21410	1556186..1558390	+	2205	WP_060401829.1	AAA family ATPase	-
FOC30_RS30540	1558432..1559091	-	660	WP_196775721.1	hypothetical protein	-
FOC30_RS21420	1559195..1559443	-	249	WP_059478629.1	hypothetical protein	-
FOC30_RS21425	1559639..1559959	-	321	WP_024429388.1	hypothetical protein	-
FOC30_RS21430	1559956..1560246	-	291	WP_024429387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC30_RS21435	1560234..1560512	-	279	WP_004541313.1	CopG family ribbon-helix-helix protein	Antitoxin
FOC30_RS21440	1560593..1562614	-	2022	WP_155822992.1	relaxase/mobilization nuclease domain-containing protein	-
FOC30_RS21445	1562620..1562889	-	270	WP_020850841.1	ribbon-helix-helix protein, CopG family	-
FOC30_RS21450	1563381..1563638	+	258	WP_060401820.1	hypothetical protein	-
FOC30_RS21455	1563753..1564274	+	522	WP_060401821.1	PAAR domain-containing protein	-
FOC30_RS21460	1564271..1565002	+	732	WP_060401822.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1550937..1571903	20966

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 10906.47 Da
• Isoelectric Point: 9.5554

>T144051 WP_024429387.1 NZ_CP046346:c1560246-1559956 [Burkholderia multivorans]
MPQVIFAPAAIGDMQRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLPEQYREWLIDFGDSGYVARYRLDG
DTVTILAVRHQKEAGY

Nucleotide

• Length: 291 bp

>T144051 NZ_CP061699:1823365-1823712 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGTTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTTTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10810.11 Da
• Isoelectric Point: 4.9736

>AT144051 WP_004541313.1 NZ_CP046346:c1560512-1560234 [Burkholderia multivorans]
MVTATSIKLDDELKGRVQHLAEARRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT144051 NZ_CP061699:1823104-1823355 [Pseudomonas aeruginosa]
ATGCGAGTCGAGACAATTAGTTATTTGAAACGTCATGCGGCTGACCTGGATTTATCCGAGCCAATGGTCGTCACGCAGAA
CGGTGTTCCTGCCTATGTGGTTGAGTCATATGCTGAGCGGAAGCAGCGCGATGAAGCAATTGCGCTGGTGAAGTTGCTTG
CGATTGGCTCCCGCCAGTACGCAGAAGGCAAGCATCGCTCTGTTGATGATTTGAAAGCTCGCCTTTCCAGGAGGTTCGCT
CAGCCAGAATAA

Structures

Antitoxin

• AlphaFold DB: M4UBZ0