144048

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2270370..2270904 Replicon chromosome
Accession NZ_CP046344
Organism Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)


Gene name parE Uniprot ID J4RBB5
Locus tag FOC30_RS09955 Protein ID WP_006413674.1
Coordinates 2270605..2270904 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID J4RB90
Locus tag FOC30_RS09950 Protein ID WP_006413656.1
Coordinates 2270370..2270615 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC30_RS09935 2265425..2267128 + 1704 WP_155821896.1 VRR-NUC domain-containing protein -
FOC30_RS09940 2267125..2269425 + 2301 WP_155821897.1 ATP-dependent DNA helicase -
FOC30_RS09945 2269462..2270232 - 771 WP_006403543.1 helix-turn-helix domain-containing protein -
FOC30_RS09950 2270370..2270615 + 246 WP_006413656.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
FOC30_RS09955 2270605..2270904 + 300 WP_006413674.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FOC30_RS09960 2271015..2272316 - 1302 WP_006397058.1 UDP-N-acetylglucosamine 1-carboxyvinyltransferase -
FOC30_RS09965 2272487..2273215 + 729 WP_012216991.1 HNH endonuclease -
FOC30_RS09970 2273250..2274557 - 1308 WP_155821898.1 shikimate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-94)

Antitoxin

Antitoxin ParD

(1-80)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11542.08 Da        Isoelectric Point: 8.4461

>T144048 WP_006413674.1 NZ_CP046344:2270605-2270904 [Burkholderia multivorans]
MPVKARTVRLTPLAEADLEAIWAYTYERWSLGQAERYIGELSTAFERLARRESVGWPSRAGGNYSRYLVGSHVVFYRETT
ETLDVIRVLHQRMDVDRHL

Download         Length: 300 bp

>T144048 NZ_CP061685:84573-84929 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8632.71 Da        Isoelectric Point: 6.4604

>AT144048 WP_006413656.1 NZ_CP046344:2270370-2270615 [Burkholderia multivorans]
MARNTSISLGDHLAEFVDMQVASGRYGSASDVVRAGLRLLETQETELRALQEALKAGEASGTPAPFDSQAFLARMRAKHA
G

Download         Length: 246 bp

>AT144048 NZ_CP061685:84922-85224 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGAGAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3KLL7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3KUX0

References