Detailed information of TA system TA144047

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-PumB/upstrm_HI1419-dnstrm_HI1420
• Location: 1539038..1539658
• Replicon: chromosome
• Accession: NZ_CP046344
• Organism: Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: FOC30_RS06740
• Protein ID: WP_043279067.1
• Coordinates: 1539341..1539658 (-)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: PumB
• Uniprot ID: B9B269
• Locus tag: FOC30_RS06735
• Protein ID: WP_006398012.1
• Coordinates: 1539038..1539337 (-)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC30_RS06710	1534280..1535548	+	1269	WP_155821535.1	Rieske 2Fe-2S domain-containing protein	-
FOC30_RS06715	1535563..1536051	+	489	WP_006398008.1	aromatic-ring-hydroxylating dioxygenase subunit beta	-
FOC30_RS06720	1536069..1536395	+	327	WP_006404219.1	non-heme iron oxygenase ferredoxin subunit	-
FOC30_RS06725	1536385..1537605	+	1221	WP_155821536.1	FAD-dependent oxidoreductase	-
FOC30_RS06730	1537719..1539005	+	1287	WP_035954116.1	DUF445 domain-containing protein	-
FOC30_RS06735	1539038..1539337	-	300	WP_006398012.1	putative addiction module antidote protein	Antitoxin
FOC30_RS06740	1539341..1539658	-	318	WP_043279067.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
FOC30_RS06750	1540021..1541661	+	1641	WP_006398015.1	acetolactate synthase large subunit	-
FOC30_RS06755	1541690..1543123	+	1434	WP_155821537.1	aldehyde dehydrogenase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (19-89)

Antitoxin

• Uncharacterized protein HI1420 (4-96)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 12124.97 Da
• Isoelectric Point: 10.2349

>T144047 WP_043279067.1 NZ_CP046344:c1539658-1539341 [Burkholderia multivorans]
MPYLAPTFSIRTTAVFDAWFAGLQDRTAKRRIQARIDRLSMGNLGNWKSVGSPVYEMRIDHGPGYRVYFVRRRTIWIVLL
CGGDKSTQRDDIRAAHAMLEHLDLE

Nucleotide

• Length: 318 bp

>T144047 NZ_CP061683:465247-465636 [Acinetobacter seifertii]
TTGATCAACCAATTGAATTTTAAACTGAAATATAGCCGTTTCGCGATTGTATTTCAGTTTTTTATTGGCCTATGTTTAGC
AGCTCTGTTTTATCAGCTGATACCAATACTCTGGTGGTTGGTTACGCTCTGTTTATTATTTATAAGTTTTATTTTCTTTT
TAAAGCGACCACAGCTCGTTCAAATTGCCTATTTAGATCAGAAATTATGGTCTCTTAGCTTTCATTCAGAACAAACCATT
TCTCGTGTAGAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGGTCTATTTTAAGGGTGATAAAACATTAACTTC
TGTTATTTGGTTTGATCAAATGTCCTTATCTCAATGGAAACAGCTTAAGACTTTAGAAAAATTCTATTAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 10605.00 Da
• Isoelectric Point: 6.6381

>AT144047 WP_006398012.1 NZ_CP046344:c1539337-1539038 [Burkholderia multivorans]
MSKISTRPWDSAEHLKTDDDMAEYFEACLQEGGDDPAFIAHALGVIARARGMSQVARDAGLSREGLYKALSHDGNPSFGT
ILKVIKALGLQLHGAKAHA

Nucleotide

• Length: 300 bp

>AT144047 NZ_CP061683:464995-465240 [Acinetobacter seifertii]
ATGACCTTGGAAGAACGTAAAGTAGTTTATCGCGCACGCCGCGGTTTAAAGGAAATTGATGTCTATTTTGACCCGTATGT
GAAAAATTATTATTTAAAGGCAGATCCAGCAGAAAAAGCATTGTTTGCTGAATTAGTAGAGCAGGAAGATCCTGATTTAC
TTGACTGGTTTATGGAAGTATCTGAACCGCCGCGTACAGAATTACGTGATTTTATTCATAAATTAAAGCATTATGTTCAT
GGCTGA

Structures

Antitoxin

• AlphaFold DB: A0A0H3KTI5