Detailed information of TA system TA144046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 557892..559195
• Replicon: chromosome
• Accession: NZ_CP046344
• Organism: Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: FOC30_RS02365
• Protein ID: WP_155820940.1
• Coordinates: 558584..559195 (+)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: FOC30_RS02360
• Protein ID: WP_155820938.1
• Coordinates: 557892..558449 (+)
• Length: 186 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FOC30_RS02340	552972..553988	+	1017	WP_155820932.1	AraC family transcriptional regulator	-
FOC30_RS02345	554094..554732	+	639	WP_155820934.1	cysteine hydrolase	-
FOC30_RS02350	554905..555636	-	732	WP_155820936.1	ribonuclease T2	-
FOC30_RS02355	555978..557381	-	1404	WP_060144518.1	hypothetical protein	-
FOC30_RS02360	557892..558449	+	558	WP_155820938.1	helix-turn-helix domain-containing protein	Antitoxin
FOC30_RS02365	558584..559195	+	612	WP_155820940.1	HD domain-containing protein	Toxin
FOC30_RS02370	559257..560795	-	1539	WP_155820942.1	MFS transporter	-
FOC30_RS02375	560973..561893	+	921	WP_006406123.1	LysR family transcriptional regulator	-
FOC30_RS02380	561940..563079	-	1140	WP_035955456.1	enoyl-CoA hydratase/isomerase family protein	-
FOC30_RS02385	563076..563867	-	792	WP_035955458.1	enoyl-CoA hydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (6-189)

Antitoxin

• Cro/C1-type helix-turn-helix domain (12-64)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22576.32 Da
• Isoelectric Point: 5.3083

>T144046 WP_155820940.1 NZ_CP046344:558584-559195 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLELCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHAQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTHTHRP

Nucleotide

• Length: 612 bp

>T144046 NZ_CP061682:c48780-48424 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 186 a.a.
• Molecular weight: 20310.26 Da
• Isoelectric Point: 8.1892

>AT144046 WP_155820938.1 NZ_CP046344:557892-558449 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVTG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCSWTRIMLSDGSAARLVETL

Nucleotide

• Length: 558 bp

>AT144046 NZ_CP061682:c48431-48129 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGACAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA