Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 557892..559195 Replicon chromosome
Accession NZ_CP046344
Organism Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FOC30_RS02365 Protein ID WP_155820940.1
Coordinates 558584..559195 (+) Length 204 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag FOC30_RS02360 Protein ID WP_155820938.1
Coordinates 557892..558449 (+) Length 186 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC30_RS02340 552972..553988 + 1017 WP_155820932.1 AraC family transcriptional regulator -
FOC30_RS02345 554094..554732 + 639 WP_155820934.1 cysteine hydrolase -
FOC30_RS02350 554905..555636 - 732 WP_155820936.1 ribonuclease T2 -
FOC30_RS02355 555978..557381 - 1404 WP_060144518.1 hypothetical protein -
FOC30_RS02360 557892..558449 + 558 WP_155820938.1 helix-turn-helix domain-containing protein Antitoxin
FOC30_RS02365 558584..559195 + 612 WP_155820940.1 HD domain-containing protein Toxin
FOC30_RS02370 559257..560795 - 1539 WP_155820942.1 MFS transporter -
FOC30_RS02375 560973..561893 + 921 WP_006406123.1 LysR family transcriptional regulator -
FOC30_RS02380 561940..563079 - 1140 WP_035955456.1 enoyl-CoA hydratase/isomerase family protein -
FOC30_RS02385 563076..563867 - 792 WP_035955458.1 enoyl-CoA hydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

5'-deoxynucleotidase YfbR/HDDC2

(6-189)

Antitoxin

Cro/C1-type helix-turn-helix domain

(12-64)


Sequences

Toxin        


Download         Length: 204 a.a.        Molecular weight: 22576.32 Da        Isoelectric Point: 5.3083

>T144046 WP_155820940.1 NZ_CP046344:558584-559195 [Burkholderia multivorans]
MNPDTIRARLDFLREAERLKDVLRSGRTSSGRRESTAEHSWRLCLMALVFADALPGIDTLKLLELCVVHDLGEALHGDIP
ATEQAAHPEKNMHERDDLLTLTAALDPVLRNELVALWDEYDAAASPEARAAKALDKLETILQHAQGANPPDFDYAFNLGY
GRRYTDAAPLFSAIRAIVDADTQRRIDAQAQTSSQTQTHTHRP

Download         Length: 612 bp

>T144046 NZ_CP061682:c48780-48424 [Acinetobacter seifertii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGCACAGCAAGATCAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ATATGAAAGACCTACGTGTTCAGCATCGAGGTAAATCACTGAGAGCCTTTTTCGCGTTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGTGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAAAT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 186 a.a.        Molecular weight: 20310.26 Da        Isoelectric Point: 8.1892

>AT144046 WP_155820938.1 NZ_CP046344:557892-558449 [Burkholderia multivorans]
MPDSPLHTPPLGPQLKRWRLLHRVKQSHAAALFGVAQSTISRWEAGVQQMSPDERATAERLLAARLDSAGDHALARLVTG
SAGRMHLVCDLTHRLLACSPSRAAEFSQPLPMLLGTSLWRYATEEIVRMETALDTLGWHDCAGPPSVEFDTGTNASRVVP
IHRSRCSWTRIMLSDGSAARLVETL

Download         Length: 558 bp

>AT144046 NZ_CP061682:c48431-48129 [Acinetobacter seifertii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAATCGCTCTCCAGACAGTCAAGCTCGTATTCAACAAATGGCGGATGAATT
ATTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAATTGGCTGCAACCCTTGGAATCA
AACAGCCTTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTCGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTCAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References