Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-StbC |
Location | 386616..387307 | Replicon | chromosome |
Accession | NZ_CP046344 | ||
Organism | Burkholderia multivorans strain FDAARGOS_722 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | J4S1H9 |
Locus tag | FOC30_RS01680 | Protein ID | WP_006416197.1 |
Coordinates | 386616..387071 (-) | Length | 152 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | A0A132F1C7 |
Locus tag | FOC30_RS01685 | Protein ID | WP_012216644.1 |
Coordinates | 387068..387307 (-) | Length | 80 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
FOC30_RS01655 | 381617..382411 | + | 795 | WP_060181520.1 | AraC family transcriptional regulator | - |
FOC30_RS01660 | 383040..383990 | + | 951 | WP_155820826.1 | DMT family transporter | - |
FOC30_RS01665 | 384186..384761 | + | 576 | WP_155820827.1 | permease | - |
FOC30_RS01670 | 384856..384990 | - | 135 | WP_006396654.1 | entericidin A/B family lipoprotein | - |
FOC30_RS01675 | 385223..386518 | + | 1296 | WP_012216646.1 | aspartate carbamoyltransferase | - |
FOC30_RS01680 | 386616..387071 | - | 456 | WP_006416197.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
FOC30_RS01685 | 387068..387307 | - | 240 | WP_012216644.1 | Arc family DNA-binding protein | Antitoxin |
FOC30_RS01690 | 387612..389858 | + | 2247 | WP_035955274.1 | TonB-dependent siderophore receptor | - |
FOC30_RS01695 | 389862..390617 | + | 756 | WP_048804528.1 | sel1 repeat family protein | - |
FOC30_RS01700 | 390614..391297 | + | 684 | WP_035955277.1 | Fe2+-dependent dioxygenase | - |
FOC30_RS01705 | 391703..391942 | + | 240 | WP_006416205.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 152 a.a. Molecular weight: 16207.59 Da Isoelectric Point: 7.2060
>T144045 WP_006416197.1 NZ_CP046344:c387071-386616 [Burkholderia multivorans]
MILVDTNVIAEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFAVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK
MILVDTNVIAEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFAVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK
Download Length: 456 bp
>T144045 NZ_CP061681:c1146215-1145934 [Acinetobacter seifertii]
ATGAGCTATAACTTAGACTTTTTAGAAGAAGCATTAGAAGAATGGAATAAGCTTAATCCTAGTATTAAGCAACCAATGAA
AAAGAAACTGATGAAAGTCTTAGAGAATCCTAGAATCCCTAAGAATAAGCTATCAGGGCATCCTAACCGATATAAAATTA
AACTTCGTAGTGTTGGCTATCGTTTGGTTTATGAGATCATAGATGATGAGGTTGTTGTATTAGTAATTGCTGTAGGCAGA
CGTGAAAATAATGCTGTCTACAATACGGCGGGCTCACGATAA
ATGAGCTATAACTTAGACTTTTTAGAAGAAGCATTAGAAGAATGGAATAAGCTTAATCCTAGTATTAAGCAACCAATGAA
AAAGAAACTGATGAAAGTCTTAGAGAATCCTAGAATCCCTAAGAATAAGCTATCAGGGCATCCTAACCGATATAAAATTA
AACTTCGTAGTGTTGGCTATCGTTTGGTTTATGAGATCATAGATGATGAGGTTGTTGTATTAGTAATTGCTGTAGGCAGA
CGTGAAAATAATGCTGTCTACAATACGGCGGGCTCACGATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8716.94 Da Isoelectric Point: 5.1133
>AT144045 WP_012216644.1 NZ_CP046344:c387307-387068 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE
Download Length: 240 bp
>AT144045 NZ_CP061681:c1146453-1146205 [Acinetobacter seifertii]
ATGACTCAACTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCTATGGATACTGTATTAGCAGG
TAAAGGTGAAGCTGTTGCTATTCTTAACCGTAATACCCCTGCTTTCTACTGTATTCCTGCTGATCTATATGAAAATATGA
TTGAACAGCTAGAGGACTTAGAACTCAATAAAATTGCAGATACTCGTGCGAATCAAAAGCGTATTCGAGTAAACATAAAT
GAGCTATAA
ATGACTCAACTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCTATGGATACTGTATTAGCAGG
TAAAGGTGAAGCTGTTGCTATTCTTAACCGTAATACCCCTGCTTTCTACTGTATTCCTGCTGATCTATATGAAAATATGA
TTGAACAGCTAGAGGACTTAGAACTCAATAAAATTGCAGATACTCGTGCGAATCAAAAGCGTATTCGAGTAAACATAAAT
GAGCTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | J4S1H9 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A132F1C7 |