Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 386616..387307 Replicon chromosome
Accession NZ_CP046344
Organism Burkholderia multivorans strain FDAARGOS_722

Toxin (Protein)


Gene name vapC Uniprot ID J4S1H9
Locus tag FOC30_RS01680 Protein ID WP_006416197.1
Coordinates 386616..387071 (-) Length 152 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A132F1C7
Locus tag FOC30_RS01685 Protein ID WP_012216644.1
Coordinates 387068..387307 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FOC30_RS01655 381617..382411 + 795 WP_060181520.1 AraC family transcriptional regulator -
FOC30_RS01660 383040..383990 + 951 WP_155820826.1 DMT family transporter -
FOC30_RS01665 384186..384761 + 576 WP_155820827.1 permease -
FOC30_RS01670 384856..384990 - 135 WP_006396654.1 entericidin A/B family lipoprotein -
FOC30_RS01675 385223..386518 + 1296 WP_012216646.1 aspartate carbamoyltransferase -
FOC30_RS01680 386616..387071 - 456 WP_006416197.1 type II toxin-antitoxin system VapC family toxin Toxin
FOC30_RS01685 387068..387307 - 240 WP_012216644.1 Arc family DNA-binding protein Antitoxin
FOC30_RS01690 387612..389858 + 2247 WP_035955274.1 TonB-dependent siderophore receptor -
FOC30_RS01695 389862..390617 + 756 WP_048804528.1 sel1 repeat family protein -
FOC30_RS01700 390614..391297 + 684 WP_035955277.1 Fe2+-dependent dioxygenase -
FOC30_RS01705 391703..391942 + 240 WP_006416205.1 type II toxin-antitoxin system Phd/YefM family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Arc-like DNA binding domain

(7-46)


Sequences

Toxin        


Download         Length: 152 a.a.        Molecular weight: 16207.59 Da        Isoelectric Point: 7.2060

>T144045 WP_006416197.1 NZ_CP046344:c387071-386616 [Burkholderia multivorans]
MILVDTNVIAEPLRREPSAAVIEWLDAQNVETLFLAAISLAEMRFAVAALPEGRRRDWLAQSIEHRVVPVFRGRILPFDD
AASKAYARIRAHARAGGNAIAPADGYIAATAEANGLIVATRDVAPFEAAGLRVIDPWASQGAPVRQGIASK

Download         Length: 456 bp

>T144045 NZ_CP061681:c1146215-1145934 [Acinetobacter seifertii]
ATGAGCTATAACTTAGACTTTTTAGAAGAAGCATTAGAAGAATGGAATAAGCTTAATCCTAGTATTAAGCAACCAATGAA
AAAGAAACTGATGAAAGTCTTAGAGAATCCTAGAATCCCTAAGAATAAGCTATCAGGGCATCCTAACCGATATAAAATTA
AACTTCGTAGTGTTGGCTATCGTTTGGTTTATGAGATCATAGATGATGAGGTTGTTGTATTAGTAATTGCTGTAGGCAGA
CGTGAAAATAATGCTGTCTACAATACGGCGGGCTCACGATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8716.94 Da        Isoelectric Point: 5.1133

>AT144045 WP_012216644.1 NZ_CP046344:c387307-387068 [Burkholderia multivorans]
MPVITVRNLPDEVHRALRVRAALHGRSTEAEVRDILEQAVLSEGRVKLGTLLAEIGREAGGVDLDIQRDKTPTDPMSFE

Download         Length: 240 bp

>AT144045 NZ_CP061681:c1146453-1146205 [Acinetobacter seifertii]
ATGACTCAACTAATCCATGCACGAATGACTGCAAGTATTACTGAACTCAAAAAGAGTCCTATGGATACTGTATTAGCAGG
TAAAGGTGAAGCTGTTGCTATTCTTAACCGTAATACCCCTGCTTTCTACTGTATTCCTGCTGATCTATATGAAAATATGA
TTGAACAGCTAGAGGACTTAGAACTCAATAAAATTGCAGATACTCGTGCGAATCAAAAGCGTATTCGAGTAAACATAAAT
GAGCTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB J4S1H9

Antitoxin

Source ID Structure
AlphaFold DB A0A132F1C7

References